{"id":"W2904054431","doi":"10.1523/jneurosci.2024-18.2018","title":"The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory","year":2018,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Queensland; National Institutes of Health; Westpac Bicentennial Foundation","keywords":"Immediate early gene; Memory consolidation; DNA methylation; Infralimbic cortex; DNA demethylation; Biology; Neuroscience; DNA repair; Histone; Epigenetics; DNA damage; Gene expression; Prefrontal cortex; Cell biology; Gene; Genetics; DNA; Hippocampus; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010497,0.000216792,0.0001645469,0.0001972033,0.0001125344,0.0003332889,0.0001525734,0.000118223,0.0004274177],"category_scores_gemma":[0.0001366035,0.0001356276,0.0002110736,0.0001043118,0.0002850025,0.0001752015,0.0003009192,0.0004151517,0.0001177154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112223,"about_ca_system_score_gemma":0.0002519995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350579,"about_ca_topic_score_gemma":0.001784805,"domain_scores_codex":[0.9998981,0.000007725598,0.000007393736,0.00003196628,0.00002079512,0.00003405864],"domain_scores_gemma":[0.9998904,0.000005820437,0.00004969847,0.00001090281,0.000014551,0.00002854115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006938336,0.000007543032,0.001045344,0.00002408288,0.000005233902,0.00003582581,0.00003683373,0.0000592407,0.9968591,0.0001207366,0.00001488458,0.001721826],"study_design_scores_gemma":[0.00001998315,0.0002230738,0.07815205,0.00002138256,0.00004127996,0.000465273,0.0001885805,0.001597122,0.9163307,0.0003402656,0.002607688,0.00001255285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991127,0.002005907,0.005690952,0.0001085,0.00001540131,0.00001091108,0.0001805421,0.00008060893,0.0007802834],"genre_scores_gemma":[0.9969695,0.0005715067,0.001341106,0.00004250889,0.000003021954,0.000006576397,0.0001267246,0.00001059941,0.000928521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350579,"threshold_uncertainty_score":0.002685428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913860930712583,"score_gpt":0.2708675426909782,"score_spread":0.2517289333838523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}