{"id":"W2904107848","doi":"10.1016/j.ccell.2018.12.010","title":"Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; McGill University Health Centre; Ontario Genomics; Hospital for Sick Children; University Health Network; Health Sciences Centre; Occupational Cancer Research Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Kingston General Hospital; Princess Margaret Cancer Centre; SickKids Foundation; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Cancer Society Research Institute; Pancreatic Cancer Canada Foundation; Hebrew University of Jerusalem; Government of Ontario; National Cancer Institute; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Pancreatic cancer; Biology; Transcriptome; Cancer research; Tumor progression; Cell cycle; Suppressor; Gene; Cancer; Pancreas; Adenocarcinoma; Cell cycle progression; Gene expression; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003234047,0.0001282089,0.0005138544,0.0001432335,0.00001713307,0.000005958124,0.00006099912,0.0001065869,0.000905881],"category_scores_gemma":[0.00001956295,0.0001002668,0.00004224154,0.0001492246,0.00008107295,0.00007796467,0.00001795411,0.0002061416,0.000006250556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773223,"about_ca_system_score_gemma":0.0003629624,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007613297,"about_ca_topic_score_gemma":0.00210297,"domain_scores_codex":[0.9988922,0.0001272542,0.0003095563,0.0002490503,0.0001982392,0.0002236234],"domain_scores_gemma":[0.9994958,0.0001145062,0.0000940353,0.0001489291,0.00005957194,0.000087133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005162904,0.0001635494,0.5112954,0.0004051156,0.0000143015,0.000006426269,0.0005868188,0.00001571565,0.4854963,0.00003997235,0.0001042244,0.001355883],"study_design_scores_gemma":[0.003733614,0.0002608257,0.970189,0.0006381204,0.0001110607,0.000004066329,0.0004199087,0.0006341258,0.02367931,0.0001111192,0.0001191043,0.00009977601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742316,0.02121313,0.000007931965,0.0001678345,0.0000524363,0.0008544705,0.00005832386,0.0000074284,0.003406852],"genre_scores_gemma":[0.9934936,0.004241876,0.000774795,0.000117648,0.00003985751,0.0001888669,0.00004411783,0.00001454806,0.001084673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.461817,"threshold_uncertainty_score":0.9989951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081901684438989,"score_gpt":0.3410881687195375,"score_spread":0.3202691518751476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}