{"id":"W2904140705","doi":"10.1002/cjp2.108","title":"You won't believe this old test … that does cheap single‐cell mutation detection","year":2018,"lang":"en","type":"letter","venue":"The Journal of Pathology Clinical Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Foothills Medical Centre; University of Calgary","funders":"Cancer Research UK","keywords":"Immunohistochemistry; Context (archaeology); Mutation; Loss function; Function (biology); Biology; Computational biology; Cancer research; Genetics; Molecular biology; Gene; Phenotype; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.01031537,0.0002550629,0.0004887009,0.000164424,0.0002553148,0.00005220278,0.0008878994,0.001792861,0.0001253403],"category_scores_gemma":[0.00445387,0.000147907,0.0003896455,0.0001528255,0.001075152,0.00000728085,0.0002780282,0.004448609,0.00009853975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008567837,"about_ca_system_score_gemma":0.0003706543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002006434,"about_ca_topic_score_gemma":0.00002717911,"domain_scores_codex":[0.9946901,0.00241639,0.001028161,0.0004300422,0.0008643351,0.0005710058],"domain_scores_gemma":[0.9952772,0.001792223,0.000826433,0.0007386014,0.001253292,0.0001123035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005826309,0.0002758012,0.0004892547,0.0001202471,0.0001420014,0.0005652984,0.0002038236,0.00001233317,0.2298572,2.090056e-7,0.7554315,0.01231969],"study_design_scores_gemma":[0.002717681,0.01383383,0.0008396223,0.0003825826,0.0004089463,0.002855003,0.0003763909,0.0001421802,0.329614,0.001462506,0.6466834,0.0006839266],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8565862,0.002719117,0.001335809,0.1345954,0.002697737,0.0004392795,0.00006945666,0.00001576969,0.001541259],"genre_scores_gemma":[0.829424,0.009268004,0.0008321155,0.1038819,0.03664342,0.00002251161,0.0001583318,0.0001531359,0.01961659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1087481,"threshold_uncertainty_score":0.999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.112039808689897,"score_gpt":0.4195185500383176,"score_spread":0.3074787413484206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}