{"id":"W2904140705","doi":"10.1002/cjp2.108","title":"You won't believe this old test … that does cheap single‐cell mutation detection","year":2018,"lang":"en","type":"letter","venue":"The Journal of Pathology Clinical Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Foothills Medical Centre; University of Calgary","funders":"Cancer Research UK","keywords":"Immunohistochemistry; Context (archaeology); Mutation; Loss function; Function (biology); Biology; Computational biology; Cancer research; Genetics; Molecular biology; Gene; Phenotype; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005530371,0.000923639,0.0009909661,0.0007511997,0.00147996,0.002103318,0.001305475,0.01470441,0.01003946],"category_scores_gemma":[0.02883151,0.0004608655,0.001040425,0.0003651569,0.004114823,0.004689962,0.001099005,0.02618539,0.01218737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001424704,"about_ca_system_score_gemma":0.0006998766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067662,"about_ca_topic_score_gemma":0.001849183,"domain_scores_codex":[0.9969332,0.0008495017,0.0003298731,0.0004007072,0.001204594,0.0002820558],"domain_scores_gemma":[0.9877775,0.007112295,0.0005409995,0.0008985203,0.002589614,0.001081099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001842887,0.0001194208,0.003251577,0.000181017,0.00005017722,0.004771402,0.0001873891,0.0001281081,0.002436034,0.006721064,0.9085118,0.07345771],"study_design_scores_gemma":[0.0000953284,0.0002862921,0.001638103,0.0002839355,0.00005241025,0.01659863,0.0004561398,0.0005660469,0.002393405,0.02120324,0.9563337,0.00009274195],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001211539,0.005543686,0.002637778,0.9552714,0.02930144,0.00003177277,0.00009052748,0.0002316432,0.005680219],"genre_scores_gemma":[0.01948524,0.008623922,0.008413043,0.8834912,0.05351015,0.0001263373,0.0001631303,0.0001736671,0.02601342],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01470441,"threshold_uncertainty_score":0.03358531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.112039808689897,"score_gpt":0.4195185500383176,"score_spread":0.3074787413484206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}