{"id":"W2904142983","doi":"10.1111/jcmm.14076","title":"Cell‐based high‐throughput screen for small molecule inhibitors of Bax translocation","year":2018,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Saskatchewan; Royal University Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Apoptosis; Programmed cell death; Chromosomal translocation; Cell biology; Caspase; Biology; Mitochondrion; Neurodegeneration; Small molecule; In vitro; In vivo; Chemical library; Cell; Biochemistry; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067806,0.0005209339,0.0008114165,0.0008075782,0.0002416368,0.0003771402,0.0003328361,0.0003240257,0.00190318],"category_scores_gemma":[0.0001446735,0.0001858683,0.0003253353,0.0004991414,0.0001591318,0.0002359276,0.0002627762,0.0005299872,0.0006326133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999513,"about_ca_system_score_gemma":0.0003435565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003140551,"about_ca_topic_score_gemma":0.001223025,"domain_scores_codex":[0.9998562,0.00003159416,0.00001348672,0.00002246266,0.00005631737,0.00001998038],"domain_scores_gemma":[0.9998926,0.00003596095,0.00001651208,0.00001114067,0.00002413961,0.00001951702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002851284,0.0005071067,0.000483939,0.0001694207,0.00003887776,0.0001585814,0.00002300715,0.0006894027,0.9876413,0.00009405246,0.0002938042,0.009615393],"study_design_scores_gemma":[0.0003102206,0.005313282,0.004359087,0.00002314372,0.0002349918,0.0007151469,0.00004992925,0.002369727,0.9803432,0.000120804,0.006135351,0.00002519667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969627,0.009299536,0.01300977,0.0004773966,0.00008376421,0.0007806026,0.002496538,0.0003446988,0.003880646],"genre_scores_gemma":[0.9649349,0.01083115,0.01279575,0.0002813792,0.00003878655,0.0003983202,0.004228362,0.000042268,0.006449137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190318,"threshold_uncertainty_score":0.00636673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008953741941851839,"score_gpt":0.232985214439096,"score_spread":0.2240314724972442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}