{"id":"W2904223404","doi":"","title":"Pharmacokinetic-Pharmacodynamic Modeling of Metformin for the Treatment of Type II Diabetes Mellitus","year":2010,"lang":"en","type":"article","venue":"CMBES Proceedings","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Metformin; Medicine; Pharmacodynamics; Type 2 Diabetes Mellitus; Diabetes mellitus; Pharmacokinetics; Pharmacology; Type 2 diabetes; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002403191,0.0004532631,0.0007324831,0.0002308949,0.0002156052,0.0007048176,0.0005959629,0.0007510862,0.001179161],"category_scores_gemma":[0.0006128408,0.0002245107,0.0007757742,0.0002834558,0.0001949109,0.0003774567,0.0002762277,0.0004395353,0.0002722231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005363359,"about_ca_system_score_gemma":0.00075147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006316561,"about_ca_topic_score_gemma":0.002645217,"domain_scores_codex":[0.9998745,0.00004118538,0.00000652762,0.00002405782,0.00003614852,0.00001756951],"domain_scores_gemma":[0.9998672,0.00006764315,0.00003251205,0.000004977095,0.00001885776,0.000008846152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006320271,0.00004553844,0.0008827503,0.00004784413,0.00003375961,0.0001040257,0.00001729562,0.9882519,0.003382092,0.002806503,0.0002112237,0.004153895],"study_design_scores_gemma":[0.0000137863,0.00005448463,0.0005867219,0.000004207089,0.00002482932,0.00004741939,0.000004330956,0.9969537,0.0004332692,0.001086244,0.0007830617,0.000007940114],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.301954,0.003775091,0.6634116,0.001473215,0.0001713482,0.0002799629,0.001224265,0.0004038343,0.02730687],"genre_scores_gemma":[0.9703085,0.001988441,0.01795725,0.0001347911,0.00004559716,0.0003119435,0.0003160618,0.00003107105,0.008906461],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006316561,"threshold_uncertainty_score":0.01255959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016193897128668,"score_gpt":0.2567981394539866,"score_spread":0.2466362004826999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}