{"id":"W2904261694","doi":"10.3389/fimmu.2018.03013","title":"Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Strategic Research Council; Natural Sciences and Engineering Research Council of Canada; Simon Fougner Hartmanns Familiefond; Frimodt-Heineke Fonden; Canadian Institutes of Health Research; Familien Hede Nielsens Fond; Odense Universitetshospital; Syddansk Universitet; Th. Maigaards Eftf. Fru Lily Benthine Lunds Fond af 1.6. 1978; Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond; Aase og Ejnar Danielsens Fond; Oda og Hans Svenningsens Fond; Carlsbergfondet","keywords":"CXCL1; Inflammation; Ceramide; Downregulation and upregulation; Bronchoalveolar lavage; Lung; Cytokine; Tumor necrosis factor alpha; Chemistry; Immunology; Molecular biology; Apoptosis; Biology; Medicine; Internal medicine; Biochemistry; Gene; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757425,0.0003969687,0.0004380974,0.0003889201,0.0001829535,0.0002789717,0.0003027173,0.0004511999,0.00158907],"category_scores_gemma":[0.0001739023,0.0001101858,0.0004040545,0.0001772712,0.0004708316,0.0002626382,0.0003475944,0.0007644868,0.0003158772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003137032,"about_ca_system_score_gemma":0.0003913724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000865472,"about_ca_topic_score_gemma":0.001476572,"domain_scores_codex":[0.9997773,0.00004369794,0.00004139788,0.0000486144,0.00004603163,0.00004306812],"domain_scores_gemma":[0.9998055,0.00002414849,0.00004095101,0.00002373559,0.00002445889,0.00008122083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005448978,0.00003238833,0.0005121041,0.00006932982,0.00001171418,0.0001153166,0.000008513626,0.00002528074,0.9971296,0.00004725394,0.00003273622,0.001470878],"study_design_scores_gemma":[0.00004202973,0.0005200006,0.006393758,0.00001005702,0.00004502115,0.0004275463,0.0000502972,0.0004098282,0.990211,0.00008642771,0.001798068,0.000006049612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890786,0.00391296,0.004202917,0.000398298,0.0000905366,0.0000448022,0.0008282111,0.0001473208,0.001296377],"genre_scores_gemma":[0.994252,0.001413054,0.00214877,0.00009948199,0.00001759819,0.00003189344,0.0006154374,0.00001963358,0.001402223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00158907,"threshold_uncertainty_score":0.005315959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053907989049599,"score_gpt":0.3027980510406488,"score_spread":0.2822589711501529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}