{"id":"W2904329518","doi":"10.1016/j.molcel.2018.11.006","title":"Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; SickKids Foundation; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Uehara Memorial Foundation; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Medical Research Council; Cancer Research Society; Genome Canada; Boehringer Ingelheim; University of Toronto; Eesti Teadusagentuur; AbbVie; Merck; Pfizer; Natural Sciences and Engineering Research Council of Canada; Alfred P. Sloan Foundation","keywords":"Bromodomain; Interactome; BRD4; BET inhibitor; Biology; Computational biology; Protein–protein interaction; Chromatin; Plasma protein binding; Genetics; Acetylation; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240755,0.0001895086,0.0004138255,0.0002560138,0.0002034027,0.0003458073,0.0001561772,0.0002621021,0.001965956],"category_scores_gemma":[0.0001345208,0.0001354549,0.0003287086,0.0001818459,0.0002205338,0.0002504546,0.0001922872,0.0005982892,0.00040204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806816,"about_ca_system_score_gemma":0.0001415534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004994501,"about_ca_topic_score_gemma":0.001107244,"domain_scores_codex":[0.9997774,0.00001849769,0.0000141353,0.00004801258,0.00006604652,0.00007591931],"domain_scores_gemma":[0.9999074,0.000019982,0.00002467689,0.00001019659,0.00001096215,0.00002678971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000206373,0.00002965637,0.000210279,0.00003360706,0.00001187393,0.00003273492,0.00001053162,0.00005189882,0.997853,0.00004099619,0.00004398593,0.001475034],"study_design_scores_gemma":[0.00002227254,0.0003274895,0.0219727,0.000005227368,0.00002490772,0.0002868517,0.00006432131,0.0009818739,0.9736908,0.00006864738,0.002547976,0.000006889632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935918,0.002132869,0.001931124,0.0001180192,0.00003303957,0.00002898651,0.0006736442,0.00007935054,0.001411172],"genre_scores_gemma":[0.9939163,0.001032252,0.001373443,0.0001476791,0.000008286723,0.00004671903,0.000806756,0.00003028782,0.002638189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965956,"threshold_uncertainty_score":0.006576836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007724121999411446,"score_gpt":0.2632018455588547,"score_spread":0.2554777235594433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}