{"id":"W2904329518","doi":"10.1016/j.molcel.2018.11.006","title":"Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; SickKids Foundation; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Uehara Memorial Foundation; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Medical Research Council; Cancer Research Society; Genome Canada; Boehringer Ingelheim; University of Toronto; Eesti Teadusagentuur; AbbVie; Merck; Pfizer; Natural Sciences and Engineering Research Council of Canada; Alfred P. Sloan Foundation","keywords":"Bromodomain; Interactome; BRD4; BET inhibitor; Biology; Computational biology; Protein–protein interaction; Chromatin; Plasma protein binding; Genetics; Acetylation; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827664,0.0001247093,0.0001274951,0.00004310566,0.0000588902,0.00001417571,0.0001873721,0.0001036235,0.00007486997],"category_scores_gemma":[0.00008091978,0.0001203567,0.0001569363,0.00009601741,0.00007026159,0.000004817343,0.0001580156,0.00008393598,0.00002313188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001104332,"about_ca_system_score_gemma":0.00002676612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005211992,"about_ca_topic_score_gemma":7.797644e-7,"domain_scores_codex":[0.9990763,0.00007378868,0.0002287668,0.0002702839,0.0001374225,0.0002134578],"domain_scores_gemma":[0.9995952,0.000006521062,0.00009512019,0.0001693541,0.0000632409,0.00007051034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002697475,0.00005023043,0.000430432,0.000008770415,0.00003206402,0.00001253856,0.00003249462,0.000005847733,0.9975313,0.00002146588,0.001251974,0.0005959218],"study_design_scores_gemma":[0.0004530524,0.0002450476,0.00006916704,0.00001183671,0.00001850036,0.000001804165,0.00002984119,0.00006852602,0.9806333,0.00003229664,0.01829829,0.0001383724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785112,0.0003776705,0.01078735,0.00004952414,0.0002718005,0.0001348545,0.000003673556,0.00001570689,0.009848276],"genre_scores_gemma":[0.9958451,0.00001138218,0.003271675,0.0003274434,0.0001855938,0.000008347356,0.00005153343,0.00002048669,0.0002784176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01733398,"threshold_uncertainty_score":0.4908004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007724121999411446,"score_gpt":0.2632018455588547,"score_spread":0.2554777235594433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}