{"id":"W2904401218","doi":"10.1182/blood-2018-99-110976","title":"Multicenter, Open-Label, 3-Arm Study of Gilteritinib, Gilteritinib Plus Azacitidine, or Azacitidine Alone in Newly Diagnosed FLT3 Mutated (FLT3mut+) Acute Myeloid Leukemia (AML) Patients Ineligible for Intensive Induction Chemotherapy: Findings from the Safety Cohort","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Internal medicine; Surgery; Gastroenterology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003767727,0.00203443,0.002809584,0.0004589005,0.0006207816,0.001389776,0.001007717,0.001455199,0.003912476],"category_scores_gemma":[0.001976788,0.0007372012,0.002660181,0.0004541953,0.001491005,0.001541268,0.00054683,0.003744408,0.001118592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001090535,"about_ca_system_score_gemma":0.001782587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007434913,"about_ca_topic_score_gemma":0.001579153,"domain_scores_codex":[0.9988893,0.0005338562,0.00005806554,0.0002483499,0.000101755,0.0001686469],"domain_scores_gemma":[0.9978631,0.0002609679,0.0005106298,0.0002874017,0.00014562,0.0009322938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9536244,0.01809062,0.007016917,0.0001412181,0.001430397,0.00008003317,0.0001218114,0.000488723,0.00674442,0.00007354553,0.001109797,0.01107793],"study_design_scores_gemma":[0.7250323,0.2494056,0.02011415,0.00001668824,0.001507932,0.0001726925,0.00007042173,0.0009081214,0.001442518,0.0002210566,0.001065952,0.00004258068],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957404,0.0007124485,0.0003220665,0.00028462,0.00009643437,0.0009240204,0.001179048,0.0000564939,0.0006846025],"genre_scores_gemma":[0.9934947,0.0004690942,0.0009318143,0.0006109085,0.0002658075,0.001130847,0.002061603,0.00002187759,0.001013389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003912476,"threshold_uncertainty_score":0.01992589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828679362180405,"score_gpt":0.2888090432221396,"score_spread":0.2605222496003356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}