{"id":"W2904418883","doi":"10.1016/j.devcel.2018.11.015","title":"Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma","year":2018,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Genetics; Institute of Cancer Research; Alberta Children's Hospital; University of Calgary; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Wellcome Trust; Hospital for Sick Children; Canadian Institutes of Health Research; China Scholarship Council; Canadian Cancer Society; Canada Research Chairs","keywords":"GLI2; Medulloblastoma; Biology; Sonic hedgehog; Ubiquitin ligase; Cancer research; Hedgehog; GLI1; Hedgehog signaling pathway; GLI3; Ubiquitin; Carcinogenesis; Cell biology; Transcription factor; Gene; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723471,0.0002549427,0.0001870025,0.0004539043,0.0002625708,0.0003661933,0.0002474815,0.0001629684,0.00133104],"category_scores_gemma":[0.0001778195,0.0002008432,0.000194051,0.0001481823,0.0003480894,0.0004752562,0.0002904747,0.0002831077,0.0001795324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003971088,"about_ca_system_score_gemma":0.0003015823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488753,"about_ca_topic_score_gemma":0.002051728,"domain_scores_codex":[0.999908,0.0000127192,0.000004891028,0.00002051935,0.00001927524,0.0000346354],"domain_scores_gemma":[0.9999278,0.00001519336,0.00001086079,0.00001021428,0.000009052889,0.00002687468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003373978,0.00001152355,0.0009995701,0.00001964887,0.000005048638,0.0001173621,0.00004112258,0.0000765911,0.9955441,0.0008974232,0.00003114091,0.001919013],"study_design_scores_gemma":[0.00001991813,0.0001208837,0.02771564,0.000003207222,0.00003305329,0.0003924743,0.0001573822,0.001684737,0.9676069,0.000447671,0.001810136,0.00000790468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995052,0.001538982,0.00142825,0.00004503927,0.00001548157,0.00000503392,0.00007925365,0.00003094901,0.001804891],"genre_scores_gemma":[0.9978392,0.0002268831,0.0003584251,0.000009705032,0.000004789193,0.000006438685,0.00006854993,0.000006652808,0.001479472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488753,"threshold_uncertainty_score":0.004452765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007355206751464175,"score_gpt":0.2069179129841758,"score_spread":0.1995627062327117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}