{"id":"W2904438492","doi":"10.1002/jhet.3426","title":"Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres","year":2018,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Alkylation; Cycloaddition; Structural isomer; Regioselectivity; Bioisostere; Stereochemistry; 1,2,4-Triazole; Combinatorial chemistry; Catalysis; Chemical synthesis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232126,0.0005282898,0.0002479604,0.0002208705,0.0001363273,0.0001524684,0.0004129465,0.0003202192,0.001291774],"category_scores_gemma":[0.0002662833,0.0002034371,0.0002460733,0.0002524126,0.0001876734,0.0003017955,0.0003116567,0.0005215327,0.0008383165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704077,"about_ca_system_score_gemma":0.0003928659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005571505,"about_ca_topic_score_gemma":0.001610702,"domain_scores_codex":[0.9998021,0.00003440361,0.00002001825,0.0000410523,0.00004976982,0.00005263915],"domain_scores_gemma":[0.9998838,0.00001522739,0.00004760182,0.00001972319,0.00001554838,0.00001822652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005544092,0.00002292473,0.00006218511,0.0001083099,0.000007068076,0.000113004,0.00002655773,0.0001674793,0.9958851,0.0001891291,0.00007050805,0.003292271],"study_design_scores_gemma":[0.00001717492,0.0002570416,0.0005831114,0.00000840823,0.00001135326,0.0002219458,0.000009186183,0.0002773298,0.9947751,0.00003536923,0.00379374,0.00001015586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9408431,0.007778821,0.03514298,0.0002607398,0.0001039834,0.0002407058,0.0008717725,0.0003335995,0.01442417],"genre_scores_gemma":[0.9736708,0.005232952,0.0149576,0.0001254572,0.00002752032,0.00009976944,0.0004914891,0.00008031262,0.005314109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291774,"threshold_uncertainty_score":0.004321456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817796529394339,"score_gpt":0.2692601973403407,"score_spread":0.2510822320463973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}