{"id":"W2904466277","doi":"10.1186/s40364-018-0148-5","title":"EZH2 as a therapeutic target for multiple myeloma and other haematological malignancies","year":2018,"lang":"en","type":"review","venue":"Biomarker Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Cancer Research Society","keywords":"EZH2; Medicine; Multiple myeloma; Clinical significance; Cancer research; Clinical trial; Bortezomib; Drug resistance; Oncology; Histone; Bioinformatics; Immunology; Internal medicine; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141752,0.0005971763,0.0008241758,0.001726393,0.0002575119,0.0006204161,0.000688282,0.0009978993,0.003642971],"category_scores_gemma":[0.0006398805,0.0001602748,0.0004002036,0.001218064,0.0003194185,0.001004588,0.0005293639,0.001824376,0.0015371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005254183,"about_ca_system_score_gemma":0.0007303164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006380226,"about_ca_topic_score_gemma":0.001425289,"domain_scores_codex":[0.9998714,0.00002209649,0.00001905703,0.0000235344,0.00005014241,0.00001374672],"domain_scores_gemma":[0.9997942,0.00009694522,0.00002789443,0.00000660987,0.00005036897,0.0000240196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006458753,0.00004912337,0.000143933,0.01096272,0.00008442734,0.0002820973,0.00004885357,0.0003244227,0.002052916,0.00337816,0.03852408,0.9440846],"study_design_scores_gemma":[0.00001146147,0.00005899924,0.0004793247,0.001776453,0.00007753092,0.001592745,0.00002912844,0.00005923766,0.0004032964,0.001295726,0.9942067,0.000009346953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001073004,0.9982792,0.0001194804,0.000388161,0.0002539787,0.00000322686,0.00001567883,0.000007909718,0.0008250995],"genre_scores_gemma":[0.0009178935,0.9974608,0.0001948463,0.0003144658,0.0002320227,0.000006128189,0.0000364139,0.000002145049,0.0008350787],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003642971,"threshold_uncertainty_score":0.01218694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2575034138263133,"score_gpt":0.4690893041265918,"score_spread":0.2115858903002786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}