{"id":"W2904518130","doi":"10.1021/acs.biochem.8b01123","title":"Hydrogen–Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin","year":2018,"lang":"en","type":"article","venue":"Biochemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada); York University","funders":"Natural Sciences and Engineering Research Council of Canada; Sanofi Pasteur; Sanofi Genzyme; Sanofi","keywords":"Diphtheria toxin; Epitope; Monoclonal antibody; Diphtheria; Virology; Epitope mapping; Antibody; Chemistry; Toxin; Biology; Immunology; Vaccination; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004111067,0.0004327499,0.0004785886,0.00006826198,0.0005481727,0.00005938238,0.0005107852,0.000403327,0.0005078936],"category_scores_gemma":[0.00009469289,0.0004199768,0.0002579335,0.0001321036,0.0002752743,0.0001042564,0.0002561681,0.0002232361,0.0002026366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007934431,"about_ca_system_score_gemma":0.00006185525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002644235,"about_ca_topic_score_gemma":0.000006936721,"domain_scores_codex":[0.9978574,0.00007686655,0.0005016361,0.000691117,0.00006223932,0.0008107654],"domain_scores_gemma":[0.9988717,0.00007606061,0.0002553209,0.000600483,0.0001335212,0.00006284212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109141,0.00008136082,0.00007899416,0.0001182953,0.0001754531,0.000005383882,0.0002395684,1.876961e-7,0.9930695,0.0004718966,0.002160888,0.003487524],"study_design_scores_gemma":[0.001311587,0.0001525926,0.0002999002,0.0001430174,0.00004014924,0.00005098219,0.0002548334,0.00001992544,0.9790719,0.0009455407,0.01719285,0.0005167876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884168,0.00222994,0.005127867,0.0001885713,0.001561366,0.0004952499,0.0005439318,0.0002077221,0.001228552],"genre_scores_gemma":[0.9882587,0.00008305449,0.005094155,0.0004238179,0.0005804783,0.0001494634,0.000483481,0.00006987595,0.004857018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01503196,"threshold_uncertainty_score":0.9998252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110360388728706,"score_gpt":0.2619777526600244,"score_spread":0.2408741487727373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}