{"id":"W2904518130","doi":"10.1021/acs.biochem.8b01123","title":"Hydrogen–Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin","year":2018,"lang":"en","type":"article","venue":"Biochemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada); York University","funders":"Natural Sciences and Engineering Research Council of Canada; Sanofi Pasteur; Sanofi Genzyme; Sanofi","keywords":"Diphtheria toxin; Epitope; Monoclonal antibody; Diphtheria; Virology; Epitope mapping; Antibody; Chemistry; Toxin; Biology; Immunology; Vaccination; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441695,0.0001983188,0.0001000507,0.0001753415,0.00009175988,0.0001797827,0.0002118621,0.0002054364,0.0004491812],"category_scores_gemma":[0.0001343039,0.0001116539,0.000114346,0.00007996483,0.0001477085,0.0001328357,0.0001160997,0.0002430203,0.0001010378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635648,"about_ca_system_score_gemma":0.00009787739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006274281,"about_ca_topic_score_gemma":0.0006483337,"domain_scores_codex":[0.9999288,0.000008777903,0.0000029848,0.00001445524,0.00001885671,0.00002606361],"domain_scores_gemma":[0.9999473,0.00001551772,0.00001272425,0.000004559102,0.000008908683,0.00001094711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004518682,0.000006256584,0.000331084,0.000007847373,0.000002712921,0.00001467012,0.000008700228,0.00004843928,0.9989109,0.00005315835,0.00001135492,0.0005597306],"study_design_scores_gemma":[0.00001746563,0.0001581641,0.007270065,0.000001928617,0.00001290407,0.0001449019,0.00002606739,0.002596332,0.9889411,0.00005672942,0.0007705733,0.000003795788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974245,0.0001903446,0.001818167,0.00002937183,0.000003686324,0.000004367748,0.00003701062,0.00001322369,0.0004793427],"genre_scores_gemma":[0.9975907,0.0001395638,0.001680156,0.00004920154,0.000002059503,0.000005331868,0.0001227719,0.000005034552,0.0004052476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006274281,"threshold_uncertainty_score":0.001912355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110360388728706,"score_gpt":0.2619777526600244,"score_spread":0.2408741487727373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}