{"id":"W2904585516","doi":"10.1002/pep2.24102","title":"Aza‐propargylglycine installation by aza‐amino acylation: Synthesis and Ala‐scan of an azacyclopeptide CD36 modulator","year":2018,"lang":"en","type":"article","venue":"Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Alkylation; Chemistry; Acylation; Glycine; Alanine; Residue (chemistry); Combinatorial chemistry; Semicarbazone; Peptide synthesis; Stereochemistry; Peptide; Amino acid; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004298035,0.0001473028,0.0001864633,0.00007001477,0.0001912109,0.00005254244,0.0003055255,0.00007406484,0.00007820542],"category_scores_gemma":[0.0003763419,0.0001288445,0.00005620529,0.0003569626,0.000822705,0.00003842894,0.0001502755,0.0000418087,0.000005590467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002335678,"about_ca_system_score_gemma":0.00007201978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001023079,"about_ca_topic_score_gemma":0.00004913332,"domain_scores_codex":[0.9985908,0.00003215122,0.0002668409,0.0005499769,0.0003061081,0.0002540844],"domain_scores_gemma":[0.9990445,0.00002386285,0.0001459187,0.0004149711,0.0001966987,0.0001740978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002147761,0.00004111526,0.00610358,0.0000074711,0.00001242608,2.775191e-7,0.00003615492,0.000009556633,0.9827278,0.00002744955,0.0001954193,0.01081729],"study_design_scores_gemma":[0.0001238666,0.0001223144,0.02021456,0.00001876698,0.00002540786,0.000006322331,0.00005648871,0.002178028,0.9748599,0.00006910833,0.002150469,0.0001748058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996672,0.0001129475,0.0003598814,0.0001190019,0.00002839772,0.00007902889,0.00002477466,0.00001070355,0.002593314],"genre_scores_gemma":[0.9974608,0.00004997144,0.001973526,0.0000592582,0.0001656259,0.000007861148,0.00002424863,0.00001191257,0.0002467535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01411097,"threshold_uncertainty_score":0.5254127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006222304720850157,"score_gpt":0.2419190810141315,"score_spread":0.2356967762932814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}