{"id":"W2904586743","doi":"10.1186/s13058-018-1080-1","title":"ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth","year":2018,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Dalhousie University; Breast Cancer Society of Canada; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Anoikis; Lapatinib; Cancer research; Trastuzumab; Downregulation and upregulation; Breast cancer; HER2/neu; Biology; Cancer cell; Medicine; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001408648,0.0002337863,0.0004300097,0.0004578287,0.000236238,0.00004789966,0.0005820257,0.000234915,0.001537082],"category_scores_gemma":[0.00007285629,0.0001618252,0.0002107498,0.001250546,0.0009129841,0.0001970027,0.000135485,0.0006108931,0.00004326221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009597088,"about_ca_system_score_gemma":0.001352711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005145423,"about_ca_topic_score_gemma":0.001135476,"domain_scores_codex":[0.9958953,0.0004285977,0.0005231852,0.0006119487,0.001580968,0.0009600156],"domain_scores_gemma":[0.9969912,0.0002090359,0.0001061313,0.0007456201,0.001715146,0.000232836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004126744,0.0002767752,0.0181127,0.000656874,0.00007306521,0.000002845953,0.003184282,0.00000792898,0.9138024,0.0001616753,0.005518969,0.05407569],"study_design_scores_gemma":[0.004641828,0.0005323514,0.6333859,0.001021033,0.00003100931,0.00007013972,0.0003887417,0.002657996,0.3491515,0.0006627413,0.007198585,0.000258142],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696966,0.0001683563,0.0002545969,0.02106749,0.000462424,0.003508792,0.003838153,0.00004315859,0.0009604525],"genre_scores_gemma":[0.9965585,0.000200502,0.0001631058,0.0001696768,0.001183893,0.0005033054,0.00002042651,0.00007341406,0.001127112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6152732,"threshold_uncertainty_score":0.9993756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09643598774559511,"score_gpt":0.3982481477689688,"score_spread":0.3018121600233736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}