{"id":"W2904633936","doi":"10.1093/jnci/djy196","title":"Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology","year":2018,"lang":"en","type":"review","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McMaster University; University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Clinical trial; Medicine; Drug development; Accrual; Adverse effect; Clinical study design; Intensive care medicine; Oncology; Drug; Internal medicine; Pharmacology; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007739947,0.0001745261,0.0004298142,0.0001100433,0.0001368774,0.00004658554,0.0002049766,0.0001372252,0.000004264277],"category_scores_gemma":[0.001893632,0.0001284665,0.000163579,0.00008765682,0.0001098219,0.0000167351,0.0001070882,0.0002394769,8.485247e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000508965,"about_ca_system_score_gemma":0.007968596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230881,"about_ca_topic_score_gemma":0.0004028301,"domain_scores_codex":[0.9986705,0.0001043412,0.000668161,0.0001898611,0.0002319293,0.0001352253],"domain_scores_gemma":[0.9977145,0.0003321807,0.0008785066,0.00008806223,0.0009190914,0.00006768293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003637696,0.0006422796,0.00002636404,0.002237352,0.0009021399,0.00001298975,0.0004449335,0.000372306,0.0001014321,0.001879809,0.0918,0.9012166],"study_design_scores_gemma":[0.0009956545,0.0001055489,0.000007168732,0.001206568,0.0002281091,0.0001471359,0.000005784265,0.000003967349,0.000176226,0.0003302048,0.9966459,0.0001476845],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007748988,0.9947949,0.0004429293,0.000435555,0.002659676,0.0005740039,0.0002169516,9.37829e-7,0.0001001391],"genre_scores_gemma":[0.0005826716,0.9932162,0.003687312,0.0004165865,0.001866052,0.0001367789,0.0000298505,0.00001718259,0.00004738862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.904846,"threshold_uncertainty_score":0.9976553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1813974995147051,"score_gpt":0.4705519108260129,"score_spread":0.2891544113113078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}