{"id":"W2904639297","doi":"10.1371/journal.pone.0208978","title":"Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Toxin; Neutralization; Single-domain antibody; Clostridium difficile toxin A; Immunogen; Clostridium difficile toxin B; Epitope; Monoclonal antibody; Clostridium difficile; Antibody; Oligopeptide; Epitope mapping; Molecular biology; Biology; Chemistry; Virology; Microbiology; Peptide; Biochemistry; Immunology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572777,0.0002658169,0.0002402912,0.0001659445,0.0001491091,0.0001953254,0.0001713953,0.0002566416,0.0006248474],"category_scores_gemma":[0.0001069761,0.0001218007,0.0002400038,0.0001552622,0.0001744897,0.0001032893,0.0002717266,0.000443052,0.0001781841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002833579,"about_ca_system_score_gemma":0.0001641039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001243374,"about_ca_topic_score_gemma":0.001440131,"domain_scores_codex":[0.9998399,0.00002577782,0.00001092466,0.00002707037,0.00005253316,0.00004366889],"domain_scores_gemma":[0.9999511,0.00001399329,0.0000110762,0.00000557774,0.000006521861,0.00001164039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004974477,0.00002190475,0.0002441982,0.00001468247,0.000005444189,0.00001953372,0.000007783491,0.0001002486,0.9983805,0.00001940298,0.00001899592,0.00111751],"study_design_scores_gemma":[0.00002997938,0.0005186621,0.004957158,0.000004266193,0.00001749624,0.0003852075,0.00002409965,0.001009062,0.9913319,0.00002148828,0.001696191,0.000004492746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960352,0.0006236602,0.002662325,0.00004110369,0.0000105906,0.00002924015,0.0001212539,0.00001685546,0.0004599228],"genre_scores_gemma":[0.9941934,0.0004825659,0.00393438,0.0000578684,0.000007622551,0.00001539918,0.0004136589,0.000004932493,0.0008901425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243374,"threshold_uncertainty_score":0.002472222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03543199361941168,"score_gpt":0.2551342974835613,"score_spread":0.2197023038641496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}