{"id":"W2904677338","doi":"10.1182/blood-2018-99-115362","title":"PRM-151 in Myelofibrosis: Efficacy and Safety in an Open Label Extension Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Medicine; Myelofibrosis; Ruxolitinib; Internal medicine; Essential thrombocythemia; Bone marrow; Fibrosis; Surgery; Gastroenterology; Polycythemia vera","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002213673,0.001112536,0.00202661,0.0002996764,0.0002957943,0.0006530402,0.0005766398,0.001059245,0.002683532],"category_scores_gemma":[0.0007386302,0.0003433368,0.001179945,0.0002625115,0.000716641,0.0009013454,0.0003418245,0.001891183,0.0007154182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003859653,"about_ca_system_score_gemma":0.0007495146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001867959,"about_ca_topic_score_gemma":0.000345801,"domain_scores_codex":[0.9995075,0.0002408979,0.00003432607,0.00007328246,0.00004168275,0.0001022687],"domain_scores_gemma":[0.9992129,0.0001145651,0.0001641727,0.0001209206,0.00006107919,0.0003264372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7740799,0.07154799,0.007890841,0.0009048904,0.0009048335,0.0004749086,0.0003194409,0.0009923886,0.058361,0.0002405175,0.001658331,0.08262493],"study_design_scores_gemma":[0.2721863,0.699801,0.01954468,0.00003674394,0.0004245088,0.0004623644,0.000049888,0.0005898703,0.004679795,0.0001182044,0.002070565,0.00003605559],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966101,0.0008702511,0.0003449887,0.0001014889,0.00004057831,0.0009683899,0.0004929064,0.00004488886,0.0005263606],"genre_scores_gemma":[0.9941751,0.0006900487,0.000854225,0.0003204007,0.0001468508,0.001200318,0.001452139,0.00001246166,0.001148455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002683532,"threshold_uncertainty_score":0.01170713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05360718723972167,"score_gpt":0.3555293526470686,"score_spread":0.301922165407347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}