{"id":"W2904696250","doi":"10.1007/s00204-018-2370-1","title":"Re: Gi et al. 2018, In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats, Archives of Toxicology 92:3207–3221","year":2018,"lang":"en","type":"letter","venue":"Archives of Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"In vivo; Carcinogen; Toxicology; Chemistry; Pharmacology; Biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005870358,0.000573793,0.002259771,0.001441075,0.0000448992,0.000007315818,0.00052624,0.0007547917,0.00005541595],"category_scores_gemma":[0.0003839308,0.0005949501,0.0005494648,0.0005042767,0.002172859,0.00001296233,0.0008695069,0.000745464,1.995479e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002734306,"about_ca_system_score_gemma":0.0002985711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008738729,"about_ca_topic_score_gemma":0.0120098,"domain_scores_codex":[0.9949751,0.001483292,0.001482029,0.001163868,0.000279213,0.0006164465],"domain_scores_gemma":[0.996457,0.001292842,0.001277172,0.0007336155,0.0001312333,0.0001080957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001331854,0.0004940712,0.02541975,0.0004797106,0.002323233,0.00006572136,0.002322699,0.0002253676,0.9649115,0.0001568032,0.001983186,0.0002861355],"study_design_scores_gemma":[0.001877108,0.004320124,0.1717872,0.0001689847,0.0009344741,0.00002390672,0.0004797431,0.0009464473,0.8170527,0.0003921174,0.00143003,0.0005872161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827481,0.002356593,0.0005376812,0.01015563,0.0000966353,0.0008604635,0.002624729,0.000004121819,0.0006160669],"genre_scores_gemma":[0.9829611,0.00266954,0.002846601,0.01088471,0.00006360626,0.00004269575,0.0003879442,0.00004450736,0.00009931331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1478588,"threshold_uncertainty_score":0.9996502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702880681404574,"score_gpt":0.2934815209418999,"score_spread":0.2764527141278542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}