{"id":"W2904699632","doi":"10.1101/500785","title":"Human Gene Expression Variability and its Dependence on Methylation and Aging","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Biology; Gene expression; Gene; Genetics; Population; DNA methylation; Phenotype; Regulation of gene expression; Methylation; Gene expression profiling; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006714097,0.00009193154,0.0002020793,0.0004294532,0.000110559,0.000249727,0.0001149614,0.0001809523,0.0006105123],"category_scores_gemma":[0.001346184,0.00009488603,0.0001621733,0.0004485901,0.0002611351,0.000136696,0.0001499766,0.0002449116,0.0001146101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810303,"about_ca_system_score_gemma":0.0001010621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009472738,"about_ca_topic_score_gemma":0.0008569619,"domain_scores_codex":[0.9996351,0.0001236451,0.0000243408,0.0001187629,0.00007645624,0.00002160798],"domain_scores_gemma":[0.9990231,0.0005034397,0.0002476254,0.0001115941,0.00008361625,0.00003069995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007297284,0.00003089801,0.3010676,0.0001301978,0.000228378,0.000182426,0.0003014919,0.002848919,0.651046,0.0009292593,0.0003387386,0.04216648],"study_design_scores_gemma":[0.000006790968,0.0001864857,0.9058841,0.00001184687,0.00006960864,0.0007355053,0.00006249755,0.00879515,0.08072659,0.001586988,0.001912981,0.00002140019],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733406,0.002385271,0.02193156,0.0001349283,0.00001343509,0.00001437856,0.0008645621,0.00007364971,0.001241544],"genre_scores_gemma":[0.9946649,0.0002917477,0.004354709,0.00004663847,0.00001344118,0.00001618163,0.0003202175,0.00001641191,0.0002757953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009472738,"threshold_uncertainty_score":0.003550828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610853575478218,"score_gpt":0.2559960314214088,"score_spread":0.2398874956666266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}