{"id":"W2904702421","doi":"10.18192/uojm.v8i2.3462","title":"Antisense Oligonucleotide Gene Therapy for Neuromuscular Disorders","year":2018,"lang":"en","type":"article","venue":"University of Ottawa Journal of Medicine","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Spinal muscular atrophy; Antisense therapy; Amyotrophic lateral sclerosis; Medicine; Genetic enhancement; Neuromuscular disease; Oligonucleotide; Bioinformatics; Duchenne muscular dystrophy; Disease; Muscular dystrophy; Gene; Computational biology; Neuroscience; Pharmacology; Biology; Genetics; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293877,0.0003056373,0.0003174891,0.0004853649,0.0001770753,0.0003832262,0.0001865603,0.0004225653,0.002812753],"category_scores_gemma":[0.0002190649,0.00007628063,0.0001976869,0.0002261123,0.000367746,0.0003410348,0.000237859,0.0008346424,0.0008077141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004810757,"about_ca_system_score_gemma":0.0004132854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119054,"about_ca_topic_score_gemma":0.00355058,"domain_scores_codex":[0.9998754,0.00001983923,0.00001310683,0.00001654547,0.00005780667,0.00001723513],"domain_scores_gemma":[0.9999417,0.00001724665,0.00001032673,0.000002978594,0.00001851972,0.000009276509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004203768,0.0002058693,0.0007256318,0.002097202,0.00006587166,0.001087834,0.0002589039,0.0004845623,0.3580331,0.01759931,0.04779255,0.5712288],"study_design_scores_gemma":[0.0001573951,0.001005192,0.001722581,0.0005994312,0.0001133514,0.005236879,0.00009272085,0.0005489917,0.1040979,0.00293782,0.8834469,0.00004090581],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05086019,0.8473603,0.03350745,0.008353826,0.005369604,0.0002301179,0.0005357959,0.0007674746,0.05301526],"genre_scores_gemma":[0.2104817,0.7066607,0.0217734,0.00403371,0.001263777,0.000264075,0.0007665942,0.0001045813,0.05465136],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002812753,"threshold_uncertainty_score":0.009409547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186668908676218,"score_gpt":0.2752854854751777,"score_spread":0.2566185946075559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}