{"id":"W2904706725","doi":"10.1016/j.virol.2018.12.010","title":"A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells","year":2018,"lang":"en","type":"article","venue":"Virology","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal","keywords":"Vero cell; Biology; Interferon; Virology; Mutant; Virus; Gene; Mutation; Open reading frame; Stop codon; Genetics; Molecular biology; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918655,0.0006809754,0.0005536824,0.0005726268,0.0002901531,0.0004157038,0.0003570332,0.0006019096,0.00259382],"category_scores_gemma":[0.0003043883,0.000231629,0.0006977684,0.0002992461,0.0005049596,0.0001777334,0.0003282274,0.0008083127,0.0006508702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003391978,"about_ca_system_score_gemma":0.0002289171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350348,"about_ca_topic_score_gemma":0.0008129579,"domain_scores_codex":[0.9996921,0.00007308415,0.00005153958,0.00005902245,0.00006770081,0.00005665636],"domain_scores_gemma":[0.9995419,0.0001348761,0.0001203527,0.00005324609,0.00002455421,0.0001250783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100635,0.00002285662,0.0001582879,0.00001187076,0.000007987835,0.0001820165,0.00001339813,0.00006328393,0.9991135,0.00005543112,0.00001301211,0.0002482462],"study_design_scores_gemma":[0.00004851034,0.0005674338,0.009371767,0.00001442348,0.0000469577,0.002050226,0.000114097,0.002471598,0.9839872,0.00007565341,0.00122469,0.00002734759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975628,0.0001509766,0.001222602,0.00005767572,0.00004944438,0.00002241554,0.0002398544,0.00004637694,0.0006478839],"genre_scores_gemma":[0.9973687,0.0001142272,0.000934123,0.0000344586,0.00001503108,0.00001324945,0.0003285901,0.00004823768,0.001143366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00259382,"threshold_uncertainty_score":0.008677185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03527519810287071,"score_gpt":0.3203949344854098,"score_spread":0.2851197363825391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}