{"id":"W2904730875","doi":"10.1371/journal.pone.0208828","title":"Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Novo Nordisk Fonden; Familien Hede Nielsens Fond; H. Lundbeck A/S; Jascha Fonden; Augustinus Fonden; Lundbeckfonden; Strategic Research Council; Novo Nordisk","keywords":"Haplogroup; Mitochondrial DNA; Single-nucleotide polymorphism; Population stratification; Genetics; Biology; Schizophrenia (object-oriented programming); Nuclear gene; Haplotype; Nuclear DNA; Human mitochondrial DNA haplogroup; Allele; Gene; Medicine; Genotype; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001598476,0.0001939493,0.0003657011,0.0008672197,0.0004922258,0.0005008543,0.0002694116,0.0002223436,0.001365485],"category_scores_gemma":[0.002805288,0.0001395677,0.0001756178,0.0009831814,0.0006114178,0.0003535579,0.0007548605,0.0003508655,0.0001810233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001408337,"about_ca_system_score_gemma":0.0001713997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127501,"about_ca_topic_score_gemma":0.004321222,"domain_scores_codex":[0.9988326,0.0005089673,0.0001220674,0.0002866454,0.000168852,0.00008081559],"domain_scores_gemma":[0.9969952,0.001480116,0.0006860888,0.0005059819,0.00017426,0.0001582946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005345875,0.00003639554,0.8968059,0.00008941712,0.0006500152,0.0005546581,0.001231315,0.0004209807,0.07622251,0.00116535,0.0001773535,0.02211141],"study_design_scores_gemma":[0.000007514548,0.00005970891,0.9940859,0.0000169505,0.00007248609,0.00074753,0.0002670815,0.0005675441,0.002139208,0.001352361,0.0006750097,0.000008607431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956173,0.0005033709,0.002632235,0.0001718783,0.000007783379,0.000006901303,0.0002576123,0.00001405038,0.0007887871],"genre_scores_gemma":[0.9989121,0.00008829578,0.0006562601,0.00004207829,0.000005460944,0.000006331918,0.0001517769,0.000008467438,0.0001292424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598476,"threshold_uncertainty_score":0.008453667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738188570976553,"score_gpt":0.2481008773224791,"score_spread":0.2107189916127136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}