{"id":"W2904731075","doi":"10.1096/fj.201801292r","title":"Nanoparticle‐mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"California Sea Grant, University of California, San Diego; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Planning and Budgeting Committee of the Council for Higher Education of Israel; Australia-Israel Scientific Exchange Foundation, Swinburne University of Technology; Diabetes Research Center; Vlaams Instituut voor Biotechnologie; Ben-Gurion University of the Negev; University of California, Los Angeles; National Institutes of Health; Azrieli Foundation","keywords":"Lipotoxicity; Cell biology; Function (biology); Chemistry; Mitochondrion; Biology; Endocrinology; Diabetes mellitus; Insulin resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271977,0.0002620134,0.0003091369,0.0001502239,0.0000820873,0.0002172849,0.0001496451,0.0003496059,0.0004260768],"category_scores_gemma":[0.00010252,0.00008924349,0.000263153,0.00007765161,0.0001178232,0.000194083,0.0001830101,0.0003369326,0.0001470767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001354933,"about_ca_system_score_gemma":0.000148778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761163,"about_ca_topic_score_gemma":0.0003067077,"domain_scores_codex":[0.9999279,0.000008006248,0.000008826405,0.00001639995,0.00001906205,0.00001985504],"domain_scores_gemma":[0.9999418,0.000007262865,0.0000178421,0.000007635599,0.00001300461,0.00001239077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007280836,0.00001853439,0.00003777385,0.00002401597,0.000003306326,0.00002362712,0.00000663644,0.00003622128,0.9990323,0.00002115853,0.00001326279,0.0007105034],"study_design_scores_gemma":[0.00001388134,0.0003064207,0.0008501745,0.000004567811,0.00001250582,0.00008999591,0.00001115872,0.0006136611,0.9974607,0.00002078548,0.0006131647,0.000002956756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947844,0.001015485,0.00331279,0.00005951991,0.00003712561,0.00002051992,0.00009256161,0.0001054801,0.0005720293],"genre_scores_gemma":[0.9952753,0.0007550436,0.002141588,0.00005637361,0.000009915701,0.00004208219,0.0002325806,0.00002299677,0.001464106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004260768,"threshold_uncertainty_score":0.001425385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545848307636209,"score_gpt":0.237770472629125,"score_spread":0.2223119895527629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}