{"id":"W2904798486","doi":"10.1136/annrheumdis-2018-213336","title":"Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer; AbbVie; Bristol-Myers Squibb; GlaxoSmithKline; Amgen","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Pharmacodynamics; Osteoarthritis; Pharmacokinetics; Adverse effect; Randomized controlled trial; Gastroenterology; Surgery; Anesthesia; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006486471,0.0003969352,0.001622471,0.0002785354,0.0002547154,0.0001128229,0.0003397209,0.00006929809,0.0001987637],"category_scores_gemma":[0.0007273071,0.0002498704,0.0001970472,0.0003392457,0.001074772,0.0003906047,0.0001743696,0.0001755836,0.00000442284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002874332,"about_ca_system_score_gemma":0.0002324224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004249736,"about_ca_topic_score_gemma":0.0001866259,"domain_scores_codex":[0.9964402,0.0006296198,0.001086659,0.0004509783,0.0008322447,0.0005603183],"domain_scores_gemma":[0.9972325,0.0004485752,0.0005448114,0.0008185901,0.0006456588,0.0003098448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6331815,0.05208877,0.2327481,0.001087067,0.005063584,0.0001222615,0.02680449,0.00003763215,0.004224779,0.0003737558,0.001156388,0.04311175],"study_design_scores_gemma":[0.7648668,0.02786748,0.1888501,0.006184916,0.0001982549,0.00003693984,0.006579146,0.000176868,0.004003093,0.0006762198,0.00005770388,0.0005024794],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923069,0.002815675,0.00001936651,0.0001517598,0.000141934,0.004222779,0.0001882795,0.00002534336,0.0001279033],"genre_scores_gemma":[0.9987297,0.0007796698,0.00007792526,0.00008036337,0.00003462411,0.0001700904,0.00003455543,0.00004540936,0.000047652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1316854,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225408008750231,"score_gpt":0.2816255934890825,"score_spread":0.2693715134015802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}