{"id":"W2904798486","doi":"10.1136/annrheumdis-2018-213336","title":"Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer; AbbVie; Bristol-Myers Squibb; GlaxoSmithKline; Amgen","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Pharmacodynamics; Osteoarthritis; Pharmacokinetics; Adverse effect; Randomized controlled trial; Gastroenterology; Surgery; Anesthesia; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002831496,0.002292904,0.004516183,0.0004816022,0.0005873383,0.001265857,0.001192962,0.002402822,0.006418665],"category_scores_gemma":[0.002311964,0.001442145,0.001427848,0.0005894896,0.001883311,0.001269369,0.0004716734,0.00306293,0.001687151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009395589,"about_ca_system_score_gemma":0.00180567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202908,"about_ca_topic_score_gemma":0.002779627,"domain_scores_codex":[0.9989333,0.0005883022,0.00007123587,0.0001556412,0.00009405933,0.0001574875],"domain_scores_gemma":[0.9987022,0.0003150103,0.0002908716,0.0001054757,0.00009861099,0.0004879133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9713218,0.01017371,0.0006048082,0.0006472881,0.0004738787,0.00005214901,0.00007712653,0.0002626207,0.006773744,0.00007047428,0.0004728959,0.009069514],"study_design_scores_gemma":[0.919844,0.07789773,0.001347865,0.0000174414,0.0001285342,0.00003074454,0.00001681608,0.000131074,0.0002255315,0.00004636721,0.0003045955,0.00000931202],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774308,0.005769831,0.001329588,0.0006912178,0.0008180742,0.01029101,0.001234091,0.0002060878,0.002229352],"genre_scores_gemma":[0.9759969,0.003700532,0.002071241,0.001529342,0.0007305037,0.009978843,0.001253022,0.00004095287,0.004698612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006418665,"threshold_uncertainty_score":0.02147263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225408008750231,"score_gpt":0.2816255934890825,"score_spread":0.2693715134015802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}