{"id":"W2904806928","doi":"10.1101/491100","title":"Targeting the CALCB/RAMP1-axis inhibits growth of Ewing sarcoma","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Deutsche Krebshilfe; Ludwig-Maximilians-Universität München; Medizinischen Fakultät, Ludwig-Maximilians-Universität München; China Scholarship Council; Studienstiftung des Deutschen Volkes; Deutsche Forschungsgemeinschaft","keywords":"Gene knockdown; Enhancer; Biology; FLI1; Gene; Molecular biology; Gene expression; RNA interference; Cancer research; Transcription factor; Cell biology; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000947486,0.0002577222,0.0003259649,0.0002664621,0.00008282666,0.0002439379,0.0001331657,0.0001596643,0.001191493],"category_scores_gemma":[0.00008228338,0.0001023961,0.0002254337,0.0001535308,0.000198736,0.0001161453,0.0001587164,0.000661491,0.0003423052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221228,"about_ca_system_score_gemma":0.0002084495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480761,"about_ca_topic_score_gemma":0.0007950254,"domain_scores_codex":[0.9998786,0.000009726463,0.0000112393,0.00002659129,0.0000414848,0.00003229635],"domain_scores_gemma":[0.9999398,0.000009748697,0.00001339177,0.000007363131,0.000007077301,0.00002267258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001774169,0.00005798198,0.0001619104,0.00005002708,0.000006576372,0.0000163497,0.000007411841,0.00008322416,0.9973243,0.00004328278,0.0001150577,0.001956475],"study_design_scores_gemma":[0.00004789343,0.0007244425,0.004951742,0.000006243089,0.00002549661,0.0001091516,0.00003311005,0.001482056,0.988151,0.00004614387,0.004418074,0.000004706481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924203,0.002984219,0.001657739,0.0001392531,0.00007221897,0.00005222295,0.0008960592,0.0002887249,0.001489343],"genre_scores_gemma":[0.9941621,0.001233977,0.001060005,0.00006623159,0.0000126872,0.00005613689,0.001055269,0.00003194286,0.002321735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191493,"threshold_uncertainty_score":0.003985941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916226254950655,"score_gpt":0.2420945399088684,"score_spread":0.2229322773593618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}