{"id":"W2904827603","doi":"10.1038/s41385-018-0114-4","title":"Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis","year":2018,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Children's Hospital of Eastern Ontario; University of Ottawa; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Crohn's and Colitis Foundation; National Institute of Dental and Craniofacial Research; Israeli Centers for Research Excellence; Israel Science Foundation; Cincinnati Children's Hospital Medical Center; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Immunology; Antimicrobial peptides; Lachnospiraceae; Dysbiosis; Immune system; Crohn's disease; Biology; Disease; Defensin; Pathogenesis; Medicine; Internal medicine; Antimicrobial; Gut flora; Gene; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001924181,0.0002785329,0.0002702638,0.0002422371,0.00009247023,0.00003220724,0.0002604084,0.0002608444,0.00004240629],"category_scores_gemma":[0.0006482237,0.0002966482,0.00009081326,0.000189754,0.0003774031,0.00003012525,0.0002915344,0.0001508115,0.00002995339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006040562,"about_ca_system_score_gemma":0.0001260881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308398,"about_ca_topic_score_gemma":0.0001386224,"domain_scores_codex":[0.9980685,0.0002240611,0.000521753,0.0005937442,0.0001571519,0.0004348108],"domain_scores_gemma":[0.9985564,0.00004309066,0.0002321365,0.0006230904,0.0004129035,0.0001323388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01075547,0.001126886,0.816204,0.00009546304,0.0002547566,0.0002696085,0.0004780563,0.000004004611,0.1652168,0.00008939399,0.0008528915,0.004652583],"study_design_scores_gemma":[0.003529864,0.0003239257,0.9837359,0.00001591142,0.0001225376,0.00000253654,0.0000781356,0.00001517528,0.01159879,0.00002297196,0.0002583295,0.0002958898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972576,0.001113752,0.00001770361,0.00009466044,0.0008432622,0.0005040584,0.00006156894,0.00002395017,0.00008343654],"genre_scores_gemma":[0.9983146,0.0004625996,0.000149815,0.0001088326,0.0001696831,0.0001204013,0.0005812003,0.00004420301,0.00004872369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1675319,"threshold_uncertainty_score":0.9999486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025198309235815,"score_gpt":0.2411690350291107,"score_spread":0.2309170519367526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}