{"id":"W2904831083","doi":"10.1002/anie.200705310","title":"Catalytic Synthesis of β<sup>3</sup>‐Amino Acid Derivatives from α‐Amino Acids","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Enantiopure drug; Expansive; Catalysis; Carbonylation; Amino acid; Chemistry; Yield (engineering); Ring (chemistry); Organic chemistry; Combinatorial chemistry; Enantioselective synthesis; Biochemistry; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123642,0.0004697906,0.0002425421,0.0001546734,0.0001522376,0.0001906835,0.0003495141,0.0001821897,0.002132814],"category_scores_gemma":[0.0001824685,0.0001503003,0.0002094062,0.0001968278,0.0001810699,0.0002917225,0.0002618788,0.0004997398,0.001392214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321278,"about_ca_system_score_gemma":0.0003255665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005396357,"about_ca_topic_score_gemma":0.0005781775,"domain_scores_codex":[0.9999169,0.00001074466,0.000008332873,0.00001432098,0.0000162849,0.00003333515],"domain_scores_gemma":[0.9999155,0.000009270198,0.00002662846,0.000009039828,0.00001982019,0.00001980184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002110722,0.00003058242,0.0003279427,0.0003999602,0.00002237201,0.0006215565,0.0001420174,0.0005038694,0.9737796,0.003440161,0.001074578,0.0194463],"study_design_scores_gemma":[0.00003897776,0.0002949715,0.0008885544,0.0000244643,0.00001811874,0.0006581746,0.00003766803,0.0004929131,0.9679456,0.0005704524,0.02901034,0.00001972266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8799384,0.009451836,0.04565089,0.0006326987,0.0007196083,0.0001916305,0.001465525,0.001189425,0.06076002],"genre_scores_gemma":[0.9731951,0.005221413,0.01251669,0.0002259649,0.00004296745,0.00007317896,0.000620024,0.0001453016,0.00795935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002132814,"threshold_uncertainty_score":0.007134914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02096147120018029,"score_gpt":0.241348119389044,"score_spread":0.2203866481888637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}