{"id":"W2904833368","doi":"10.1126/scitranslmed.aat3392","title":"Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models","year":2018,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"Amgen; Howard Hughes Medical Institute","keywords":"Medicine; Obesity; Pharmacology; Internal medicine; Endocrinology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006310654,0.001132449,0.001117895,0.0007660686,0.0002882242,0.0004707053,0.0006879151,0.0006600787,0.001729353],"category_scores_gemma":[0.0002448453,0.0002830402,0.0006260709,0.0003053795,0.0005626627,0.0005872597,0.0002576885,0.003019381,0.0004291637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003160242,"about_ca_system_score_gemma":0.0004849101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004312464,"about_ca_topic_score_gemma":0.001188809,"domain_scores_codex":[0.9997765,0.00005311241,0.00001591193,0.00004171195,0.00005130633,0.00006142467],"domain_scores_gemma":[0.999739,0.00002833933,0.0000679903,0.00002401291,0.00003137548,0.0001094263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008595292,0.008645846,0.0003736726,0.0009217948,0.0002215366,0.0002368314,0.00006219759,0.0006329506,0.9457971,0.0005701596,0.001695099,0.03224745],"study_design_scores_gemma":[0.007263253,0.1368803,0.01047887,0.0001799224,0.0009857587,0.0009401655,0.0001798051,0.003029494,0.8165011,0.0008885381,0.02259839,0.00007431029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714003,0.01326472,0.006117325,0.001480961,0.0006192431,0.0005242818,0.001344134,0.0006804758,0.004568567],"genre_scores_gemma":[0.9637392,0.01797545,0.008168912,0.0008868568,0.0003034462,0.001002238,0.002286458,0.00009360773,0.005543976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729353,"threshold_uncertainty_score":0.005785227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244989206711328,"score_gpt":0.3185768657134429,"score_spread":0.2940779450423101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}