{"id":"W2904851566","doi":"10.3892/mmr.2018.9753","title":"Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes","year":2018,"lang":"en","type":"article","venue":"Molecular Medicine Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Manitoba","keywords":"KLF4; Downregulation and upregulation; Biology; Cell growth; Cell cycle; SOX2; Cancer research; Reprogramming; Apoptosis; Melanoma; Cell biology; Cell; Embryonic stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008706843,0.000253166,0.0001394647,0.0002199404,0.00008834386,0.0001964301,0.00008770625,0.0001321732,0.001071811],"category_scores_gemma":[0.00009583738,0.00009265621,0.0001786683,0.0001310073,0.0001232678,0.0001444774,0.0001474576,0.0003240148,0.0001799187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336119,"about_ca_system_score_gemma":0.0001415553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001951279,"about_ca_topic_score_gemma":0.0004089427,"domain_scores_codex":[0.9999068,0.00001298769,0.00001073852,0.00001877023,0.00003348801,0.00001722379],"domain_scores_gemma":[0.9999492,0.000009288387,0.0000177406,0.000005636449,0.000009388004,0.000008696108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003198367,0.00001194019,0.00031074,0.00005261601,0.000005193023,0.00007318872,0.00002203358,0.00005410997,0.9953354,0.0002374591,0.00003730407,0.003827907],"study_design_scores_gemma":[0.00001485603,0.0002026123,0.005162714,0.0000151912,0.00003464601,0.0003684953,0.00005448702,0.0006815552,0.9816021,0.000154026,0.01170338,0.000005965535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836951,0.004288602,0.007281354,0.0001065208,0.00006506156,0.00006188952,0.0003313696,0.000102961,0.004067001],"genre_scores_gemma":[0.990418,0.003112903,0.002692921,0.00006504617,0.00001587741,0.0000507162,0.0003724007,0.00001847952,0.003253551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071811,"threshold_uncertainty_score":0.003585577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192740525033607,"score_gpt":0.2633666062015896,"score_spread":0.2514392009512535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}