{"id":"W2904853278","doi":"10.1038/s41467-018-07747-0","title":"Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Heart, Lung, and Blood Institute; Japan Society for the Promotion of Science; University of Illinois at Chicago; Core Research for Evolutional Science and Technology; University of Illinois at Urbana-Champaign; Japan Agency for Medical Research and Development","keywords":"Liver regeneration; Downregulation and upregulation; Hepatocyte; Regeneration (biology); FOXM1; Liver injury; Cell biology; Biology; Hepatectomy; Liver cytology; Cancer research; Endocrinology; Internal medicine; Medicine; Biochemistry; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078183,0.0002058468,0.0001541433,0.0001546745,0.0001407346,0.0001785739,0.00008839357,0.0001413108,0.00203505],"category_scores_gemma":[0.0000712069,0.00006533423,0.0001836563,0.00006131359,0.0002662008,0.000152289,0.0002814423,0.0003474188,0.0002261084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913401,"about_ca_system_score_gemma":0.0001408625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001761744,"about_ca_topic_score_gemma":0.0004515004,"domain_scores_codex":[0.9999403,0.000009334819,0.000003174474,0.00001447416,0.00001219572,0.00002054566],"domain_scores_gemma":[0.9999381,0.000005047295,0.00002238655,0.000005278514,0.000004721272,0.0000243848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004078918,0.00001841722,0.0008904491,0.00005960343,0.000004893317,0.00006136896,0.00001865478,0.00003523971,0.9942498,0.0002281032,0.00006151081,0.003964168],"study_design_scores_gemma":[0.00005414306,0.0007457566,0.03263532,0.00002599319,0.00003009495,0.0003589779,0.00009564109,0.0006914072,0.9595511,0.0002621494,0.005542653,0.000006868108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911501,0.003360718,0.002465058,0.0002238128,0.00004745568,0.00001629897,0.0002017793,0.00006985046,0.002464758],"genre_scores_gemma":[0.9943876,0.001254997,0.001144905,0.00006012497,0.00002226184,0.0000217651,0.0001721171,0.00001165167,0.002924619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203505,"threshold_uncertainty_score":0.006807923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783498053307194,"score_gpt":0.2904005001577961,"score_spread":0.2725655196247242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}