{"id":"W2904916806","doi":"10.1007/s12031-018-1214-z","title":"TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular Neuroscience","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Guanine nucleotide exchange factor; Guanine; Neurochemistry; Tropomyosin receptor kinase B; Nucleotide; Biology; Receptor; Cell biology; Biochemistry; Chemistry; Signal transduction; Gene; Neuroscience; Neurology; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007791905,0.0001903001,0.0002057207,0.00009274202,0.0002002407,0.0001067769,0.0003861661,0.00007719897,0.00001978235],"category_scores_gemma":[0.0004210278,0.0001427648,0.00008934661,0.000308191,0.0002869866,0.00002486482,0.0001313116,0.0002386613,0.000001485659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001479711,"about_ca_system_score_gemma":0.00004946071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006669412,"about_ca_topic_score_gemma":0.000001407304,"domain_scores_codex":[0.998379,0.0001488452,0.0004542121,0.0003548618,0.0003199965,0.0003431102],"domain_scores_gemma":[0.9990541,0.00008480626,0.000371638,0.0002029635,0.0001669412,0.0001195807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005379359,0.00002340735,0.000397436,0.000006958863,0.000005956368,0.00003147451,0.0001646545,0.0002575598,0.9945926,0.00000862963,0.003007211,0.001450293],"study_design_scores_gemma":[0.0004642363,0.0005459289,0.0004734724,0.00007264521,0.000008108819,0.0001201396,0.0001351662,0.0003421085,0.9602715,0.00004336653,0.03733914,0.0001841599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876485,0.006484589,0.004296222,0.001066057,0.0003334708,0.0001114689,0.000003653123,0.000005329299,0.00005065673],"genre_scores_gemma":[0.9968553,0.0007794355,0.0005850765,0.001247498,0.0003651811,0.000002006005,0.000002074552,0.00002743379,0.0001359845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03433193,"threshold_uncertainty_score":0.5821778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962279998425715,"score_gpt":0.2607671252518473,"score_spread":0.2411443252675901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}