{"id":"W2904923544","doi":"10.1007/s12672-018-0353-6","title":"A Targeted Bivalent Androgen Receptor Binding Compound for Prostate Cancer Therapy","year":2018,"lang":"en","type":"article","venue":"Hormones and Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; McGill University; Montreal Neurological Institute and Hospital; Jewish General Hospital","funders":"Prostate Cancer Canada; Jewish General Hospital; Movember Foundation","keywords":"Bivalent (engine); Prostate cancer; Androgen receptor; Prostate; Oncology; Computational biology; Medicine; Internal medicine; Biology; Cancer; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009693,0.0001640001,0.0002494028,0.00007837162,0.0002357283,0.00004050271,0.00004939091,0.00006285117,0.0004098773],"category_scores_gemma":[0.000004774053,0.000109352,0.00006520259,0.0001713721,0.0001774736,0.00007192413,0.00002547158,0.00007597608,0.00001233934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349334,"about_ca_system_score_gemma":0.0001903932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004282227,"about_ca_topic_score_gemma":0.00006507708,"domain_scores_codex":[0.9989685,0.0000144704,0.0001500136,0.0003045808,0.0001815266,0.0003808988],"domain_scores_gemma":[0.9994317,0.00002215321,0.00005424278,0.0001301507,0.0001997864,0.0001619602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009908177,0.0002566699,0.105154,0.0003416546,0.0009113828,0.00001721476,0.003357832,0.000001005682,0.3406775,0.00005713744,0.06392367,0.4753937],"study_design_scores_gemma":[0.0105878,0.002341383,0.01682008,0.0002858608,0.0001267502,0.00001149927,0.0004498383,0.0002836951,0.1869506,0.00009154133,0.7816912,0.0003597614],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9241698,0.07076379,0.00001206308,0.002946113,0.0002908785,0.001223267,0.0003188353,0.00004501079,0.000230247],"genre_scores_gemma":[0.8679,0.1199921,0.0002780063,0.0004666232,0.0009903171,0.001445867,0.0001185606,0.00005272222,0.008755887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7177675,"threshold_uncertainty_score":0.4487869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04501632806562778,"score_gpt":0.349986072406982,"score_spread":0.3049697443413542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}