{"id":"W2904960526","doi":"10.1016/j.neuropharm.2018.12.011","title":"Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex","year":2018,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Ventral tegmental area; Nucleus accumbens; Nicotine; Infralimbic cortex; Nicotinic agonist; Neuroscience; Psychology; Prefrontal cortex; Chemistry; Internal medicine; Endocrinology; Medicine; Dopamine; Receptor; Dopaminergic; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002327911,0.0006560608,0.0006657582,0.0002772353,0.0002454193,0.0004790983,0.0004299997,0.0004680987,0.00420508],"category_scores_gemma":[0.0004685618,0.0004033375,0.0005228589,0.0001452657,0.0005312418,0.0004931507,0.0002985013,0.001164473,0.0005688607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008507792,"about_ca_system_score_gemma":0.0005536376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003500843,"about_ca_topic_score_gemma":0.009746482,"domain_scores_codex":[0.9997011,0.00005890045,0.00001627616,0.00005775295,0.00009342306,0.00007242558],"domain_scores_gemma":[0.9994981,0.00008698932,0.00009699511,0.00007760327,0.00004221603,0.0001980773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001279732,0.0001777404,0.0007725882,0.00002859775,0.00003019254,0.00004275841,0.00002101234,0.00004820905,0.9953594,0.0001182112,0.00004127079,0.002080363],"study_design_scores_gemma":[0.0001212816,0.002816665,0.06028173,0.00001690028,0.0001639543,0.0004456775,0.00008621129,0.001977293,0.933022,0.0001909673,0.0008579733,0.0000193501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973711,0.0003300979,0.0005851865,0.0001064295,0.00003903392,0.00001721723,0.00008228949,0.00004531885,0.001423459],"genre_scores_gemma":[0.9909171,0.0004857892,0.0007693765,0.00007295263,0.00002397447,0.00002820501,0.0001685631,0.00005582968,0.007478211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00420508,"threshold_uncertainty_score":0.01406741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571696901897054,"score_gpt":0.3254116820085883,"score_spread":0.2996947129896178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}