{"id":"W2905052297","doi":"10.1007/s40259-018-0325-y","title":"Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies","year":2018,"lang":"en","type":"review","venue":"BioDrugs","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hereditary angioedema; Medicine; C1-inhibitor; Dosing; Tolerability; Kallikrein; Pharmacokinetics; Angioedema; Pharmacology; Pharmacodynamics; Internal medicine; Immunology; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001779275,0.0007539931,0.001945534,0.001492122,0.0002650432,0.001165476,0.001296001,0.001167785,0.003253832],"category_scores_gemma":[0.002023237,0.0003377145,0.001750926,0.001110587,0.0003960686,0.00124221,0.0004518754,0.002016972,0.0007722559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00053778,"about_ca_system_score_gemma":0.0009852195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007783326,"about_ca_topic_score_gemma":0.00169708,"domain_scores_codex":[0.99965,0.00009473244,0.00008322689,0.0000491211,0.00009420909,0.00002867018],"domain_scores_gemma":[0.9988631,0.0006320641,0.0001805355,0.00002273126,0.0002330989,0.00006849526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000853376,0.0003103213,0.0003978991,0.05437794,0.0006989256,0.000224912,0.0001217666,0.0004219267,0.002844208,0.001748555,0.02511771,0.9128824],"study_design_scores_gemma":[0.001494834,0.00318875,0.003359681,0.03860478,0.003644435,0.002702722,0.0001512937,0.0005005554,0.001921899,0.001839289,0.9425056,0.00008611797],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004316903,0.998148,0.0001334534,0.0003553816,0.0001480829,0.00003713965,0.00004521578,0.000008942582,0.0006921162],"genre_scores_gemma":[0.00302536,0.9950971,0.0004070372,0.0007745334,0.0001924494,0.00006645028,0.00009088517,0.000004280395,0.0003419666],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003253832,"threshold_uncertainty_score":0.01088512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1589567030262765,"score_gpt":0.4415890634976389,"score_spread":0.2826323604713624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}