{"id":"W2905066790","doi":"10.1182/blood-2018-99-116013","title":"Safety, Efficacy, Pharmacokinetic (PK) and Biomarker Analyses of BCL2 Inhibitor Venetoclax (Ven) Plus MDM2 Inhibitor Idasanutlin (idasa) in Patients (pts) with Relapsed or Refractory (R/R) AML: A Phase Ib, Non-Randomized, Open-Label Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Venetoclax; Medicine; Refractory (planetary science); Internal medicine; Pharmacokinetics; Ven; Oncology; Pharmacology; Leukemia; Chronic lymphocytic leukemia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000812775,0.0003815917,0.0008835933,0.0002218684,0.0001799151,0.0006107262,0.0003018406,0.0003917349,0.002318477],"category_scores_gemma":[0.0004271381,0.0002247988,0.0007587528,0.0002791172,0.0004261656,0.0004429291,0.0001820949,0.001093405,0.0003649142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005011876,"about_ca_system_score_gemma":0.0004591277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001988169,"about_ca_topic_score_gemma":0.0005553711,"domain_scores_codex":[0.9996997,0.0001275437,0.00002627213,0.00006309567,0.00004500184,0.00003842207],"domain_scores_gemma":[0.9996583,0.00005193349,0.0001180823,0.00003170392,0.00002365708,0.0001161616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.631933,0.04736026,0.0345336,0.001055883,0.001724183,0.0003638271,0.0002819302,0.002920606,0.1352204,0.0003435118,0.002068916,0.1421939],"study_design_scores_gemma":[0.122488,0.7888616,0.05791767,0.00007007646,0.001198062,0.0008162077,0.000123387,0.001786801,0.02094048,0.0002924373,0.005457602,0.00004773821],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971316,0.001253936,0.0002169879,0.00006184709,0.00001768223,0.0003891276,0.0003512962,0.00001371811,0.0005637837],"genre_scores_gemma":[0.9970781,0.0005767942,0.0005222185,0.0001052307,0.00003529953,0.0003211561,0.0005473283,0.000004258869,0.0008097081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318477,"threshold_uncertainty_score":0.007756054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05637307913478334,"score_gpt":0.3921033687574476,"score_spread":0.3357302896226642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}