{"id":"W2905124584","doi":"10.1016/j.devcel.2018.11.030","title":"Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood","year":2018,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fondation pour la Recherche Médicale; University of Utah; Fondation pour la recherche juridique; Fondation Bettencourt Schueller; National Institutes of Health; Center for Outcomes Research and Evaluation, Yale School of Medicine","keywords":"Biology; Lipid metabolism; Hepatocyte nuclear factor 4; Metabolism; Cell biology; Fatty acid metabolism; Metamorphosis; Fatty acid; Nuclear receptor; Genetics; Biochemistry; Gene; Transcription factor; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231298,0.0003584778,0.0002033952,0.0003653925,0.0002731067,0.0003981742,0.0003399819,0.0003332318,0.001844916],"category_scores_gemma":[0.0001887975,0.0002664073,0.0002043745,0.00009280893,0.0002973194,0.0003056268,0.0004361693,0.0007399215,0.0005011325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008488095,"about_ca_system_score_gemma":0.0004329803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002973833,"about_ca_topic_score_gemma":0.008289097,"domain_scores_codex":[0.999898,0.00000757732,0.00000600633,0.00002202191,0.00003024474,0.00003616613],"domain_scores_gemma":[0.999749,0.00003476079,0.00005908894,0.00002572435,0.00003913117,0.00009225246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008754685,0.000005229499,0.000367723,0.000009122017,0.000002997632,0.0000615541,0.000008958251,0.00003338809,0.9979505,0.0002176749,0.00006562129,0.001189675],"study_design_scores_gemma":[0.00001789058,0.00006204522,0.02059426,0.000006928582,0.00001143855,0.0001973708,0.00006309506,0.0006556964,0.9753558,0.0001381881,0.002889503,0.000007847086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903033,0.0009033786,0.003516757,0.0001752722,0.00005566923,0.00001136362,0.0004421075,0.0002174299,0.004374588],"genre_scores_gemma":[0.9879693,0.0003891198,0.002158844,0.00009854283,0.00001087521,0.0000145726,0.0005688124,0.0001485138,0.008641514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002973833,"threshold_uncertainty_score":0.006171823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007524108012140381,"score_gpt":0.2100119970059081,"score_spread":0.2024878889937678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}