{"id":"W2905137810","doi":"10.1016/s2213-2600(18)30389-8","title":"Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study","year":2018,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"Medical Research Council; GlaxoSmithKline; Asthma and Lung UK; Virginia Commonwealth University; Teva Pharmaceutical Industries; National Institute for Health and Care Research; Department of Chemical Engineering and Biotechnology, University of Cambridge; Regeneron Pharmaceuticals; Pfizer; British Lung Foundation; Rosetrees Trust; Sanofi; AstraZeneca; Amgen","keywords":"Asthma; Medicine; Biobank; Genome-wide association study; Cohort; Genetic association; Stage (stratigraphy); Internal medicine; Single-nucleotide polymorphism; Bioinformatics; Genetics; Genotype; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003138608,0.0002470582,0.0008430418,0.0002577438,0.0001221728,0.00001262044,0.0003737218,0.00007442623,0.0002429384],"category_scores_gemma":[0.001763749,0.0001514022,0.0000594139,0.0007621541,0.0002288399,0.00007747622,0.0001248027,0.0003465752,0.0001343991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527945,"about_ca_system_score_gemma":0.0001747708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003450742,"about_ca_topic_score_gemma":0.0000847578,"domain_scores_codex":[0.9968994,0.0007699584,0.0006858808,0.0003850937,0.000797272,0.0004624566],"domain_scores_gemma":[0.9981031,0.0002884027,0.000341359,0.0007505844,0.0002880911,0.0002284561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005412402,0.0003274344,0.9787217,0.00006000192,0.0000911152,0.00006966585,0.003252137,0.00003255415,0.001283871,0.00001960734,0.01338105,0.002219645],"study_design_scores_gemma":[0.004624811,0.002966256,0.9157898,0.000264306,0.00007816451,0.000002728628,0.001350284,0.000008274885,0.0001647001,0.00003369223,0.07457172,0.0001452381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804184,0.0007441023,0.00002870342,0.003599164,0.0001691246,0.001021042,0.00001973706,0.00006786312,0.0139318],"genre_scores_gemma":[0.9848148,0.00001638292,0.00003474081,0.01163334,0.003062525,0.00003482408,0.000007799015,0.0000400884,0.0003555387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06293186,"threshold_uncertainty_score":0.6174001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05740214885122156,"score_gpt":0.3288635925765057,"score_spread":0.2714614437252841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}