{"id":"W2905137810","doi":"10.1016/s2213-2600(18)30389-8","title":"Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study","year":2018,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"Medical Research Council; GlaxoSmithKline; Asthma and Lung UK; Virginia Commonwealth University; Teva Pharmaceutical Industries; National Institute for Health and Care Research; Department of Chemical Engineering and Biotechnology, University of Cambridge; Regeneron Pharmaceuticals; Pfizer; British Lung Foundation; Rosetrees Trust; Sanofi; AstraZeneca; Amgen","keywords":"Asthma; Medicine; Biobank; Genome-wide association study; Cohort; Genetic association; Stage (stratigraphy); Internal medicine; Single-nucleotide polymorphism; Bioinformatics; Genetics; Genotype; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001452764,0.000560942,0.0007188565,0.0006812474,0.001121454,0.001000707,0.0005451467,0.001312871,0.002920364],"category_scores_gemma":[0.002064276,0.0004481707,0.0007987527,0.001527209,0.0007679731,0.0004331005,0.0007775694,0.0009011591,0.000361278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988001,"about_ca_system_score_gemma":0.000287966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003190018,"about_ca_topic_score_gemma":0.003549443,"domain_scores_codex":[0.9987786,0.0003680176,0.00011479,0.0004647939,0.0001311194,0.0001426752],"domain_scores_gemma":[0.9988331,0.0002880132,0.0002976983,0.000205342,0.0000988681,0.0002769793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001049631,0.00009144754,0.991946,0.00003790668,0.0006932705,0.0008563941,0.0002750294,0.00005695571,0.002475881,0.0001104624,0.0002484617,0.00215851],"study_design_scores_gemma":[0.00003866272,0.0001394089,0.9978759,0.00001194918,0.0002328843,0.001038515,0.0001389483,0.00007994472,0.00007018456,0.00007597276,0.0002905382,0.000007067491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981115,0.0007001642,0.000213516,0.0001079396,0.00001428238,0.00001156943,0.0002855615,0.000006661983,0.0005488492],"genre_scores_gemma":[0.9991191,0.0001787998,0.0002080945,0.00006287209,0.00002153016,0.000009529709,0.0002393258,0.000004436522,0.0001562766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003190018,"threshold_uncertainty_score":0.009769559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05740214885122156,"score_gpt":0.3288635925765057,"score_spread":0.2714614437252841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}