{"id":"W2905141927","doi":"10.1158/0008-5472.can-18-2726","title":"Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canadian Centre for Applied Research in Cancer Control; Vancouver General Hospital; Alberta Health Services; Vancouver Hospital and Health Sciences Centre; Princess Margaret Cancer Centre; BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; National Institute for Health and Care Research; Japan Society for the Promotion of Science; Novo Nordisk Fonden; Vanderbilt University Medical Center; Cancer Research UK; Government of Canada; World Health Organization; European Commission; National Center for Advancing Translational Sciences; Wellcome Trust; Vanderbilt University; National Center for Research Resources; Roswell Park Cancer Institute; National Institutes of Health; Ovarian Cancer Research Fund","keywords":"DNA methylation; Cancer; Epithelial ovarian cancer; Ovarian cancer; Methylation; Oncology; Medicine; Biology; Internal medicine; DNA; Gynecology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009702006,0.000179022,0.0002704052,0.0006024023,0.0002731021,0.0002982279,0.0002192016,0.0003226893,0.001430777],"category_scores_gemma":[0.003118342,0.000151001,0.0004394685,0.0009021398,0.0001664471,0.0001280933,0.0002958147,0.0002606214,0.0001654985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001007982,"about_ca_system_score_gemma":0.0001215364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004906241,"about_ca_topic_score_gemma":0.004986531,"domain_scores_codex":[0.9994401,0.0002158327,0.00006213492,0.000169084,0.00007528615,0.00003743974],"domain_scores_gemma":[0.9988183,0.0004667024,0.0002954119,0.0002160834,0.0001084239,0.00009493668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009043038,0.000007891198,0.99558,0.000009982223,0.0002123754,0.00004047967,0.00002491776,0.0001712519,0.001865994,0.00003251234,0.0001197961,0.001844358],"study_design_scores_gemma":[0.00000797453,0.00003480229,0.998103,0.000003859516,0.00009049439,0.0001481806,0.00003511464,0.0008036427,0.0003902747,0.00007120043,0.0003088741,0.000002528529],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968979,0.0002253109,0.0009392962,0.00004547941,0.000005497116,0.000006335492,0.001644227,0.0000112898,0.0002245657],"genre_scores_gemma":[0.9985008,0.00005968577,0.0003699622,0.00001400552,0.000005796765,0.000006574467,0.0009320755,0.000002337662,0.0001086462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004906241,"threshold_uncertainty_score":0.009755373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06539679892286754,"score_gpt":0.3652184528133117,"score_spread":0.2998216538904441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}