{"id":"W2905148286","doi":"10.1161/hyp.72.suppl_1.p116","title":"Abstract P116: Induction of Human Endothelin-1 Overexpression for 3 Months Increases Plasma Aldosterone","year":2018,"lang":"en","type":"article","venue":"Hypertension","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Aldosterone; Endocrinology; Internal medicine; Mineralocorticoid receptor; Mineralocorticoid; Aldosterone synthase; Endothelin 1; Endothelin receptor; Glucocorticoid receptor; Receptor; Angiotensin II; SGK1; Epithelial sodium channel; Biology; Kidney; Zona glomerulosa; Plasma renin activity; Glucocorticoid; Renin–angiotensin system; Chemistry; Blood pressure; Medicine; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001728171,0.0005829812,0.0008124258,0.0004325055,0.0002075157,0.000487331,0.0003832354,0.0007003299,0.008680621],"category_scores_gemma":[0.0001935207,0.0002141006,0.0006077181,0.0002823112,0.0004759085,0.0004636183,0.0003459505,0.00200542,0.002095606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002697496,"about_ca_system_score_gemma":0.0002169855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000511429,"about_ca_topic_score_gemma":0.0005751131,"domain_scores_codex":[0.9996192,0.00002889975,0.00004953714,0.0001016362,0.0001057029,0.00009493672],"domain_scores_gemma":[0.9995253,0.00005164887,0.0001487268,0.00005297221,0.00003792894,0.0001834702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000893939,0.0001716305,0.0002647169,0.00005879067,0.000009590715,0.0002436717,0.00001893482,0.00001766127,0.9965833,0.00004049017,0.0001793767,0.001517865],"study_design_scores_gemma":[0.0002066485,0.00325177,0.01650759,0.00002476476,0.00005680676,0.001423562,0.0001053044,0.0003469524,0.9721214,0.00007441083,0.005864806,0.00001600489],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987866,0.00182168,0.003002797,0.0005187111,0.0003271909,0.00008961733,0.003236959,0.000416798,0.002720349],"genre_scores_gemma":[0.9589949,0.001493668,0.002854688,0.0003768761,0.0001171856,0.0002589728,0.006587238,0.0002165146,0.02910012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008680621,"threshold_uncertainty_score":0.02903956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05800698631885957,"score_gpt":0.3008658847958672,"score_spread":0.2428588984770076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}