{"id":"W2905181293","doi":"10.1074/jbc.ra117.001440","title":"High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Institute of Cancer Research; Government of Canada; Huntington Society of Canada; Krembil Foundation; McMaster University; Huntington's Disease Society of America","keywords":"Huntingtin; Huntingtin Protein; Polyglutamine tract; Biology; Nuclear transport; Neurodegeneration; Nuclear protein; Cell biology; Importin; Molecular biology; DNA damage; Nuclear localization sequence; Trinucleotide repeat expansion; Mutant; Cell nucleus; Biochemistry; Nucleus; Gene; DNA; Internal medicine; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007918477,0.0003269472,0.000121659,0.0001615866,0.0001727795,0.0001619791,0.0001524636,0.0001859093,0.001515433],"category_scores_gemma":[0.0001262633,0.00009347382,0.0001307699,0.00009718924,0.0001881981,0.000157478,0.0002558612,0.0002240905,0.0004478073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002662587,"about_ca_system_score_gemma":0.0001254291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004464762,"about_ca_topic_score_gemma":0.0008473021,"domain_scores_codex":[0.9999537,0.000009231751,0.000002321908,0.00001212242,0.00001232112,0.00001031231],"domain_scores_gemma":[0.9998963,0.00001322265,0.00004825775,0.000007551683,0.000009590459,0.00002516697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008093794,0.00001413903,0.001607073,0.00003110465,0.00000569061,0.0001785799,0.00002523341,0.0000193261,0.9960782,0.0001846617,0.00005130408,0.001723613],"study_design_scores_gemma":[0.0000137724,0.0002812207,0.07098189,0.00002447491,0.0000187112,0.001387608,0.00008412357,0.0007067065,0.920903,0.0004827055,0.005106709,0.000009080096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946674,0.00189265,0.002201619,0.00007149371,0.00001793728,0.00001158038,0.0001293764,0.00004515317,0.0009628613],"genre_scores_gemma":[0.9949217,0.000739989,0.001773277,0.0000303673,0.00001084311,0.00001248689,0.0003858352,0.000005106846,0.00212035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515433,"threshold_uncertainty_score":0.005069554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335162894357438,"score_gpt":0.2600591941227172,"score_spread":0.2265429046869734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}