{"id":"W2905205873","doi":"10.1136/thoraxjnl-2017-211440","title":"Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension","year":2018,"lang":"en","type":"article","venue":"Thorax","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Medical Research Council; Imperial College London; National Institute for Health and Care Research; Royal Brompton and Harefield NHS Foundation Trust; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Transforming growth factor; Pulmonary hypertension; Growth differentiation factor; Internal medicine; Growth factor; Atrophy; Cardiology; Endocrinology; Bone morphogenetic protein; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466003,0.0001914548,0.0001895917,0.0001769988,0.0001224125,0.0001202151,0.0001149631,0.0001948492,0.002194087],"category_scores_gemma":[0.0001379463,0.0001264515,0.0002540878,0.0001144526,0.0001980471,0.00007465889,0.0001592491,0.0003252646,0.0003185852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551313,"about_ca_system_score_gemma":0.00009337583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004574234,"about_ca_topic_score_gemma":0.0004756316,"domain_scores_codex":[0.9999131,0.00001588048,0.000008902553,0.00002228674,0.00001930638,0.00002044322],"domain_scores_gemma":[0.9998825,0.00001923521,0.00003469965,0.00001263448,0.0000100255,0.00004095006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007326253,0.0001033211,0.005286017,0.00006462366,0.00002000703,0.0005343808,0.00002535305,0.0000392322,0.9907361,0.00003764937,0.00005874609,0.002362037],"study_design_scores_gemma":[0.0002227511,0.005885175,0.1980879,0.00002672543,0.0001470392,0.008680899,0.0001154096,0.00168525,0.7812117,0.0001092981,0.003818665,0.000009157066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983546,0.0005365808,0.0006283761,0.00003108726,0.00001723305,0.00001345699,0.00008418331,0.00002243607,0.0003121511],"genre_scores_gemma":[0.9979517,0.0003662635,0.0004122325,0.00003366787,0.00001197997,0.00002134539,0.0002335089,0.000004575039,0.0009646891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002194087,"threshold_uncertainty_score":0.007339895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153588081914165,"score_gpt":0.2513085020457405,"score_spread":0.2297726212265989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}