{"id":"W2905231927","doi":"10.1186/s13073-019-0620-3","title":"BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma","year":2019,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Mount Sinai Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Mitacs; Terry Fox Research Institute","keywords":"Haploinsufficiency; Peritoneal mesothelioma; Mesothelioma; Medicine; Human genetics; Cancer research; Immunology; Computational biology; Pathology; Oncology; Biology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003461706,0.0002888071,0.0002008206,0.000831808,0.0002083137,0.0004239583,0.0002531137,0.0003148633,0.001280668],"category_scores_gemma":[0.001070215,0.0001106723,0.0001987371,0.0003142354,0.000272476,0.0001733611,0.0003757823,0.0002859137,0.0001853892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567489,"about_ca_system_score_gemma":0.00009858216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003181308,"about_ca_topic_score_gemma":0.0005474772,"domain_scores_codex":[0.9998247,0.00002360206,0.00001911887,0.00006365971,0.00004210259,0.00002692452],"domain_scores_gemma":[0.9992917,0.0001809259,0.0003134618,0.00005989688,0.00004844883,0.0001055778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005554067,0.00003188705,0.9287796,0.00003255209,0.00005659847,0.0005144926,0.00006019076,0.0003000883,0.0636178,0.00007307851,0.0001544946,0.005823803],"study_design_scores_gemma":[0.00001498098,0.0001003051,0.9893664,0.000007048904,0.00004978794,0.002424102,0.00008873612,0.001324898,0.005965126,0.0001760133,0.000478078,0.000004513829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989619,0.0002008104,0.0003372676,0.00003053835,0.000002501692,0.000008768294,0.000206791,0.00001292301,0.0002384439],"genre_scores_gemma":[0.9992712,0.00006283185,0.0002969222,0.00001101196,0.000003774192,0.000005477034,0.0002936326,0.00000511424,0.00004986794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280668,"threshold_uncertainty_score":0.004284263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009358087289234499,"score_gpt":0.2350689151297723,"score_spread":0.2257108278405378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}