{"id":"W2905241205","doi":"10.1182/blood-2018-99-112599","title":"Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Sunnybrook Health Science Centre; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Blinatumomab; Peripheral blood mononuclear cell; Oncology; Phases of clinical research; Cytokine release syndrome; Chimeric antigen receptor; Gastroenterology; Clinical trial; Leukemia; Immunotherapy; Lymphoblastic Leukemia; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557468,0.0001224715,0.0003871493,0.0003359,0.00003972479,0.000005838127,0.00009720823,0.00008195384,0.0001355008],"category_scores_gemma":[0.0001070668,0.00007951811,0.00004994385,0.001340276,0.000235615,0.00004187031,0.00008127216,0.000138993,0.000001262491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005921844,"about_ca_system_score_gemma":0.0001539099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001889954,"about_ca_topic_score_gemma":0.0002534294,"domain_scores_codex":[0.9988055,0.00007581659,0.0003037737,0.0002417686,0.0003839302,0.0001891833],"domain_scores_gemma":[0.9990482,0.0001108537,0.0001454106,0.0003600622,0.0002529772,0.00008250547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001690709,0.0005011445,0.9865667,0.00005130788,0.0009788601,0.000005931772,0.00062608,0.000003079278,0.008513245,0.00000407879,0.00002749416,0.001031343],"study_design_scores_gemma":[0.01408654,0.0008322572,0.978604,0.0000461816,0.00322985,0.000005159485,0.00002622258,0.0001761261,0.002900117,0.000002482775,0.00001362067,0.00007749361],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988079,0.000141879,0.000004921285,0.00001630252,0.00002614367,0.0003733425,0.00003230862,0.000008242428,0.0005889798],"genre_scores_gemma":[0.9992366,0.0003271383,0.00006683567,0.00002488336,0.00003432651,0.00000405099,0.00002481843,0.00001800612,0.0002633112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01239583,"threshold_uncertainty_score":0.3242655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006299406194958854,"score_gpt":0.2397061389398204,"score_spread":0.2334067327448616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}