{"id":"W2905259247","doi":"10.1016/j.bone.2018.12.011","title":"Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia","year":2018,"lang":"en","type":"article","venue":"Bone","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Alexion Pharmaceuticals","keywords":"Medicine; Hypophosphatasia; Internal medicine; Gastroenterology; Randomized controlled trial; Alkaline phosphatase; Statistical significance; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000179375,0.0001368916,0.0003213621,0.00004799697,0.00009497423,0.000005336677,0.00003857586,0.00003883666,0.00001474943],"category_scores_gemma":[0.0001663852,0.00009407866,0.00002422263,0.0001049419,0.000416799,0.00004883616,0.00006091264,0.00007451221,0.000005396227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000142648,"about_ca_system_score_gemma":0.00005016323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007007729,"about_ca_topic_score_gemma":0.00001630229,"domain_scores_codex":[0.9990904,0.00001647544,0.0001769477,0.0002575922,0.0002232525,0.000235288],"domain_scores_gemma":[0.9992648,0.00007102959,0.00006848708,0.000223273,0.0002241641,0.0001482324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2360114,0.00277847,0.1544061,0.003472959,0.001350067,0.0001835864,0.004777104,5.140179e-7,0.004471148,0.0009980919,0.02901756,0.562533],"study_design_scores_gemma":[0.05747705,0.007886089,0.9012772,0.002401144,0.0001565517,0.00007150515,0.0006929252,0.0001262413,0.01530324,0.0002098348,0.01407446,0.0003237922],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734741,0.02400805,0.00006857563,0.0007140239,0.00002360561,0.001362916,0.0002622032,0.0000200395,0.00006643665],"genre_scores_gemma":[0.9910596,0.006607231,0.001862218,0.000130547,0.0001205239,0.00002746437,0.00004676874,0.0000224595,0.0001231631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7468711,"threshold_uncertainty_score":0.3836417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141062697447674,"score_gpt":0.2975900221876091,"score_spread":0.2834837524428417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}