{"id":"W2905271172","doi":"10.1111/cbdd.13451","title":"T‐705‐modified ssRNA in complex with Lassa virus nucleoprotein exhibits nucleotide splaying and increased water influx into the RNA‐binding pocket","year":2018,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"","keywords":"Nucleoprotein; Lassa virus; Lassa fever; Virology; Nucleotide; RNA; Chemistry; Biophysics; Arenavirus; Ribonuclease; Biology; Virus; Biochemistry; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008135314,0.0002365213,0.0003827818,0.0001645632,0.0002532985,0.00004223286,0.0001679445,0.0002451398,0.0002784832],"category_scores_gemma":[0.0001537519,0.0001267568,0.00004961693,0.0002625841,0.0009371318,0.00008069439,0.0001785754,0.000701706,0.0001312461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114792,"about_ca_system_score_gemma":0.0000630369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337362,"about_ca_topic_score_gemma":0.0001050261,"domain_scores_codex":[0.9982585,0.0002488849,0.0003092913,0.0004467255,0.0001455227,0.0005910304],"domain_scores_gemma":[0.9991176,0.0002411691,0.00005221815,0.0002877779,0.0001130118,0.0001882639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00075721,0.00008368573,0.004635169,0.00002400853,0.00004940107,0.00002583363,0.0006581717,8.490388e-7,0.9895526,0.00009415018,0.0004976616,0.003621242],"study_design_scores_gemma":[0.002059127,0.000341818,0.002980568,0.00007599373,0.00003784832,0.00006524929,0.0001740482,0.0007189565,0.9915503,0.0004233387,0.001370417,0.0002023866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959893,0.00007321403,0.0003229133,0.001569861,0.00002712482,0.0006572437,0.000004441397,0.0000634817,0.001292473],"genre_scores_gemma":[0.9971954,0.00002170515,0.001311462,0.001048352,0.0001830129,0.00006414417,0.00004427508,0.00003050472,0.0001011655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003418855,"threshold_uncertainty_score":0.5168994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03585751291202934,"score_gpt":0.2996168012991979,"score_spread":0.2637592883871686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}