{"id":"W2905281204","doi":"10.3389/fnmol.2018.00454","title":"Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease","year":2018,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arizona Biomedical Research Commission; National Institute of Neurological Disorders and Stroke; Alzheimer's Association; Weston Brain Institute; Arizona Department of Health Services; National Institute on Aging; Alzheimer's Disease Research Center, Emory University; Emory University; Michael J. Fox Foundation for Parkinson's Research; U.S. Department of Veterans Affairs","keywords":"Apolipoprotein E; Allele; Genotype; Biology; Microglia; Alzheimer's disease; TREM2; Clusterin; Genetics; Disease; Internal medicine; Immunology; Inflammation; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002498354,0.0002879314,0.0002301128,0.0004596561,0.0001484044,0.0002546124,0.0001063769,0.0001804783,0.0003140413],"category_scores_gemma":[0.0002967137,0.0001355006,0.0002365414,0.000254617,0.0001945486,0.0001600668,0.0002032186,0.0001546713,0.00007034993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001561344,"about_ca_system_score_gemma":0.0000944346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006528959,"about_ca_topic_score_gemma":0.0007784371,"domain_scores_codex":[0.9998815,0.0000266208,0.00001058431,0.00003474352,0.00002139046,0.0000252058],"domain_scores_gemma":[0.9998518,0.00002587359,0.00005765259,0.00001595775,0.00001952432,0.00002913927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002472934,0.00008191403,0.06409591,0.00004207575,0.000152434,0.0003722144,0.0001319072,0.0002128984,0.9273982,0.00008627211,0.00005071651,0.004902652],"study_design_scores_gemma":[0.00001854003,0.000341421,0.9030646,0.000005145121,0.0001235578,0.0008586515,0.000129426,0.001893902,0.09306095,0.000258766,0.000232447,0.00001262313],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995957,0.00009771824,0.0001954302,0.000005246999,0.000001046981,0.000001413303,0.00004082591,0.000003443778,0.0000590547],"genre_scores_gemma":[0.9993103,0.0001020128,0.000305479,0.000008835316,0.000001151919,0.000006061101,0.000103823,0.000003141787,0.0001591476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006528959,"threshold_uncertainty_score":0.001321256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183722750297892,"score_gpt":0.2700659024982869,"score_spread":0.258228674995308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}