{"id":"W2905305487","doi":"10.1161/hyp.72.suppl_1.p151","title":"Abstract P151: Short- and Long-Term Induction of Human Endothelin-1 Overexpression in Mice Up-Regulated the Expression of <i>Khdrbs3</i> in Mesenteric Arteries","year":2018,"lang":"en","type":"article","venue":"Hypertension","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Jewish General Hospital","funders":"","keywords":"Biology; Mesenteric arteries; Gene expression; Tamoxifen; Genetically modified mouse; Transgene; Endothelin receptor; microRNA; Endothelin 1; Molecular biology; Endocrinology; Andrology; Internal medicine; Gene; Medicine; Receptor; Genetics; Artery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002861938,0.0007477589,0.0005495774,0.0005750736,0.000241758,0.0004161149,0.0003674247,0.0006051983,0.005483535],"category_scores_gemma":[0.0001685974,0.0003389062,0.0006437859,0.0002490123,0.0006531264,0.0004656938,0.000365544,0.001569778,0.001443523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820147,"about_ca_system_score_gemma":0.0002369916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003143361,"about_ca_topic_score_gemma":0.000532331,"domain_scores_codex":[0.9995692,0.00003692228,0.00005208206,0.0001590978,0.00009348943,0.00008910374],"domain_scores_gemma":[0.9995325,0.0000465547,0.0001980836,0.00004331607,0.00003073157,0.0001488878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003699425,0.00006079062,0.0001690925,0.00004629954,0.000006548822,0.00009206963,0.00001375813,0.00001582214,0.9983607,0.00006290423,0.00008386282,0.0007182942],"study_design_scores_gemma":[0.0001124013,0.001323164,0.01051578,0.00002211497,0.00005449384,0.0009483559,0.00006368679,0.0002993131,0.9825923,0.00006350042,0.003993221,0.0000116873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866129,0.0009921277,0.005734088,0.0003321578,0.000138565,0.0001229058,0.003472701,0.0004042327,0.002190259],"genre_scores_gemma":[0.9580514,0.001297106,0.008076037,0.0003751992,0.00007912577,0.0004516692,0.006223142,0.0003987227,0.02504764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005483535,"threshold_uncertainty_score":0.01834428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03225738646423788,"score_gpt":0.2827778156863132,"score_spread":0.2505204292220753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}