{"id":"W2905341752","doi":"10.1136/annrheumdis-2018-214294","title":"Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arthritis Research UK; Versus Arthritis; Kennedy Trust for Rheumatology Research; National Institute for Health and Care Research; Ontario Genomics; Genome Canada; Chugai Pharmaceutical; Wellcome Trust; Roche; University Hospitals Birmingham NHS Foundation Trust; Pfizer; Ontario Genomics Institute; Merck KGaA; Birmingham Biomedical Research Centre; Eli Lilly and Company","keywords":"Medicine; Proinflammatory cytokine; Synovitis; Immunology; Immune system; Arthritis; Rheumatoid arthritis; Cytokine; Synovial fluid; Inflammation; Pathology; Osteoarthritis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002882759,0.0003464121,0.000553103,0.0002600414,0.0001195277,0.000677996,0.0003542848,0.0004987362,0.002592058],"category_scores_gemma":[0.00014524,0.00007992519,0.000268501,0.0001784863,0.0005039556,0.0007545405,0.0002587881,0.0009146843,0.0005789583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000223276,"about_ca_system_score_gemma":0.000230771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00011858,"about_ca_topic_score_gemma":0.0003534819,"domain_scores_codex":[0.9998832,0.0000236937,0.00000655799,0.00002270332,0.00003196257,0.00003194965],"domain_scores_gemma":[0.9999124,0.00002307384,0.0000224506,0.000008731638,0.00001465326,0.00001870545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001836466,0.0008095288,0.002372163,0.002414749,0.0001454662,0.0009757092,0.000217049,0.0006006944,0.4771999,0.01200686,0.007072694,0.4943488],"study_design_scores_gemma":[0.001595039,0.01875939,0.01192913,0.001221222,0.0006837744,0.008272172,0.0004745479,0.003610059,0.2819977,0.01138282,0.6599524,0.0001217181],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1968024,0.7386829,0.03557349,0.01239931,0.00200864,0.0001733826,0.0003526469,0.0003842935,0.01362303],"genre_scores_gemma":[0.6235286,0.3368241,0.01776527,0.004550222,0.002875814,0.0002041003,0.0003059656,0.00004511343,0.0139008],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002592058,"threshold_uncertainty_score":0.008671284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269123392471438,"score_gpt":0.2915782600298009,"score_spread":0.2588870261050865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}