{"id":"W2905347751","doi":"10.3389/fnbeh.2018.00302","title":"The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia","year":2018,"lang":"en","type":"article","venue":"Frontiers in Behavioral Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University","keywords":"Phencyclidine; Schizophrenia (object-oriented programming); NMDA receptor; Neuroscience; Dopamine; Allosteric regulation; Psychology; Pharmacology; Dopamine hypothesis of schizophrenia; Medicine; Psychiatry; Dopamine receptor D2; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001711651,0.0003401047,0.0004006711,0.0003086575,0.0007338679,0.0002191069,0.003441407,0.0001141945,0.000009672533],"category_scores_gemma":[0.0005003915,0.0002141593,0.0001570526,0.002292935,0.006135546,0.0006094246,0.0004470115,0.001013585,0.0000100969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000368315,"about_ca_system_score_gemma":0.0002405089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001686187,"about_ca_topic_score_gemma":0.00002713854,"domain_scores_codex":[0.9940427,0.00154598,0.0009565864,0.001226293,0.00111098,0.001117481],"domain_scores_gemma":[0.9982502,0.0003987443,0.000298822,0.0008211074,0.00006884171,0.0001622593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004668801,0.0006567934,0.03654661,0.000004640709,4.184142e-7,0.0001155956,0.000141492,0.0002238772,0.9534957,0.00005783945,0.0006419545,0.007648171],"study_design_scores_gemma":[0.00349709,0.004033608,0.1071224,0.00004705364,0.00005863925,0.0001671918,0.0002762671,0.2009569,0.6797444,0.001811624,0.001447121,0.0008376788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935115,0.00008369941,0.0005994206,0.0007539255,0.003977021,0.000919366,0.00001996431,0.00003742197,0.00009768089],"genre_scores_gemma":[0.9966058,0.0009715129,0.0001511756,0.001640802,0.0001275981,0.00008207699,3.52064e-7,0.00002668858,0.0003940611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2737513,"threshold_uncertainty_score":0.9965692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1145543495798135,"score_gpt":0.3962930868412233,"score_spread":0.2817387372614099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}