{"id":"W2905371854","doi":"10.1002/hep.30417","title":"Entecavir and Peginterferon Alfa‐2a in Adults With Hepatitis B e Antigen–Positive Immune‐Tolerant Chronic Hepatitis B Virus Infection","year":2018,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; Genentech; Georgia Clinical and Translational Science Alliance; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences; National Institutes of Health; American Association for the Study of Liver Diseases; Bristol-Myers Squibb","keywords":"Entecavir; Medicine; HBeAg; Hepatitis B virus; Internal medicine; Gastroenterology; Nucleoside analogue; Hepatocellular carcinoma; Clinical endpoint; Hepatitis B; Immunology; Virology; Nucleoside; Virus; HBsAg; Lamivudine; Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001771233,0.0004082716,0.000889758,0.0003782844,0.0002168286,0.00002268502,0.00008741589,0.0002515242,0.0002520619],"category_scores_gemma":[0.00009882368,0.0003654158,0.00008181295,0.0003637747,0.0008061937,0.0002011164,0.000148336,0.000413864,0.000191673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004784418,"about_ca_system_score_gemma":0.0002012622,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2179793,"about_ca_topic_score_gemma":0.6329087,"domain_scores_codex":[0.9975795,0.0001985177,0.0005665236,0.0007093205,0.0002438138,0.0007023715],"domain_scores_gemma":[0.9988724,0.0001036096,0.0001861567,0.0004060608,0.0002757581,0.0001560012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008341905,0.0001883042,0.980666,0.000151793,0.0001638922,0.0005207852,0.002010107,5.265417e-7,0.001478166,0.0001513029,0.0002741054,0.01356084],"study_design_scores_gemma":[0.003215856,0.005388506,0.9731979,0.001046952,0.00008292455,0.0009890976,0.00002113692,0.003094269,0.008815924,0.00005009588,0.003713684,0.0003836583],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931772,0.002323808,0.000618675,0.0007219424,0.0004396111,0.0008840905,0.00004663633,0.0001361723,0.001651873],"genre_scores_gemma":[0.9771766,0.02149577,0.0002127799,0.0004969919,0.0002604967,0.0001569111,0.00005767389,0.00005256291,0.00009022362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4149294,"threshold_uncertainty_score":0.9998798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008483123138900803,"score_gpt":0.2540030218659991,"score_spread":0.2455198987270983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}